Inflammatory Cytokines in Maternal Circulation and Placenta of Chromosomally Abnormal First Trimester Miscarriages

Table 1

In vivo cytokine and receptors, measured in snap frozen villous tissue collected on the day of ERPC—comparison done using 2-way ANOVA, using the variables of karyotype (normal versus abnormal) and gestation (weeks). There was no significant difference between gestation and karyotype. Estimated marginal means for each marker by karyotype, adjusted for gestation, are presented here.

Cytokine/receptor	Normal karyotype; pg/g (95% CI)	Abnormal karyotype; pg/g (95% CI)	Normal versus abnormal karyotype; P value
TNFα	8.2 (5.3, 12.6)	7.2 (4.2, 12.2)	0.92
IL-10	2.2 (1.3, 3.8)	2.9 (1.6, 5.2)	0.79
TNFα/IL-10	4.5 (2.2, 9.0)	2.3 (1.3, 4.2)	0.62
TNF-R1	2499.1 (1488.8, 4195.3)	2753.26 (1927.21, 3933.4)	0.56
TNF-R2	12440.9 (6876.6, 22507.7)	12157.9 (8716.9, 16957.2)	0.68