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Clinical and Developmental Immunology
Volume 2012, Article ID 178340, 6 pages
Clinical Study

The Expression of Selected Proapoptotic Molecules in Dermatitis Herpetiformis

1Department of Dermatology and Venereology, Medical University of Lodz, Krzemieniecka Street no. 5, 94-017 Lodz, Poland
2Laboratory of Nephropathology, Medical University of Lodz, Pomorska street no. 251, 92-216 Lodz, Poland

Received 14 January 2012; Revised 6 April 2012; Accepted 25 April 2012

Academic Editor: Takashi Hashimoto

Copyright © 2012 Zebrowska Agnieszka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The role of the process of apoptosis is investigated in the pathogenesis of many autoimmune diseases; however at present, there is not much information about its role in dermatitis herpetiformis. Skin biopsies were taken from 18 DH patients and from 10 healthy subjects. The localization and expression of Bax, Fas, FasL, TRAIL, TRAIL-R in skin lesions, and perilesional skin were studied by immunohistochemistry. Expression of Bax, Fas, and Fas ligand was detected in the keratinocytes in skin biopsies from DH patients. Expression of TRAIL and TRAIL receptor was confirmed in epidermis, infiltration cells, and some fibroblasts. The expression of examined molecules in biopsies from healthy people was observed only in single cells. There were statistically significant differences between lesional, perilesional, and healthy skin of control group in Bax expression analysis and between lesional skin and control group in Fas, FasL, and TRAIL expression. There were statistically significant differences between control group and perilesional skin in Bax and FasL expression. Our results show that selected proapoptotic molecules may take part in pathogenesis of dermatitis herpetiformis, but the role of apoptosis in this process is not clear.