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Clinical and Developmental Immunology
Volume 2012, Article ID 187080, 12 pages
Research Article

Dual Functions of the C5a Receptor as a Connector for the K562 Erythroblast-Like Cell-THP-1 Macrophage-Like Cell Island and as a Sensor for the Differentiation of the K562 Erythroblast-Like Cell during Haemin-Induced Erythropoiesis

Department of Molecular Pathology, Faculty of Life Science, Kumamoto University Graduate School, Honjyo 1-1-1, Chuou-ku, Kumamoto 860-8556, Japan

Received 4 July 2012; Revised 18 October 2012; Accepted 11 November 2012

Academic Editor: Daniel Rittirsch

Copyright © 2012 Hiroshi Nishiura et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure1: Morphological changes of EGFP-ANXA3 K562 cells during the hemin-induced differentiation under monocell culture conditions

Supplementary Figure2: Effects of the K562-THP-1 cell interaction on the hemin-induced erythropoiesis

Supplementary Figure3: x1000x1000x40x40Effects of the K562-THP-1 cell interaction on the hemin-induced terminal differentiation

Supplementary Figure4: Roles of macrophages in the hemin-induced cell differentiation of K562 cells

  1. Supplementary Figures