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Clinical and Developmental Immunology
Volume 2012 (2012), Article ID 192719, 14 pages
http://dx.doi.org/10.1155/2012/192719
Review Article

Lessons from Cancer Immunoediting in Cutaneous Melanoma

1Laboratorio de Cancerología, Fundación Instituto Leloir, IIBBA-CONICET, Avenida Patricias Argentinas 435, 1405 Buenos Aires, Argentina
2Centro de Investigaciones Oncológicas, Fundación Cáncer and Instituto Alexander Fleming, 1426 Buenos Aires, Argentina

Received 23 February 2012; Accepted 28 April 2012

Academic Editor: Masoud H. Manjili

Copyright © 2012 Mariana Aris et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We will revisit the dual role of the immune system in controlling and enabling tumor progression, known as cancer immunoediting. We will go through the different phases of this phenomenon, exposing the most relevant evidences obtained from experimental models and human clinical data, with special focus on Cutaneous Melanoma, an immunogenic tumor per excellence. We will describe the different immunotherapeutic strategies employed and consider current models accounting for tumor heterogeneity. And finally, we will propose a rational discussion of the progress made and the future challenges in the therapeutics of Cutaneous Melanoma, taking into consideration that tumor evolution is the resulting from a continuous feedback between tumor cells and their environment, and that different combinatorial therapeutic approaches can be implemented according to the tumor stage.