Research Article

Gene Expression Profiling in Dermatitis Herpetiformis Skin Lesions

Table 1

Annotated genes differentially expressed in DH versus healthy controls grouped according to their function.

Functional classProbe set IDF.C.RegulationGene symbolGene titleAccession number

Immune response206486_at1.5UpLAG3Lymphocyte-activation gene 3NM_002286
204352_at1.6UpTRAF5TNF receptor-associated factor 5NM_004619
205821_at1.7UpKLRK1Killer cell lectin-like receptor subfamily K, member 1NM_007360
203717_at2.4UpDPP4Dipeptidyl peptidase 4 NM_001935
203939_at3.8UpNT5E5′-nucleotidase, ecto (CD73)NM_002526
204502_at2.0UpSAMHD1SAM domain and HD domain 1NM_015474

Inflammation206332_s_at3.1UpIFI16Interferon, gamma-inducible protein 16NM_005531
217738_at2.0UpNAMPTNicotinamide phosphoribosyltransferaseNM_005746
203176_s_at2.2UpTFAMTranscription factor A, mitochondrialNM_003201
205870_at2.2UpBDKRB2Bradykinin receptor B2NM_000623
204655_at2.2UpCCL5Chemokine (C-C motif) ligand 5NM_002985
209392_at2.3UpENPP2EctonucleotidepyrophosphataseL35594
202859_x_at2.3UpIL8Interleukin 8NM_000584
211272_s_at2.4DownDGKADiacylglycerol kinase, alpha 80 kDaAF064771
207177_at2.5UpPTGFRProstaglandin F receptor NM_000959
208782_at2.9UpFSTL1Follistatin-like 1BC000055
204563_at7.3UpSELLSelectin L NM_000655
206211_at4.3UpSELESelectin E NM_000450
217800_s_at1.9UpNDFIP1Nedd4 family interacting protein 1NM_030571
214475_x_at2.8DownCAPN3Calpain 3, (p94)AF127764
201859_at3.1UpSRGNSerglycinNM_002727
201110_s_at5.2UpTHBS1Thrombospondin 1NM_003246

Apoptosis202558_s_at1.5UpSTCHStress 70 protein chaperoneNM_006948
217786_at1.5DownPRMT5Protein arginine methyltransferase 5NM_006109
204781_s_at1.5UpFASTNF receptor superfamily, member 6NM_000043
202693_s_at1.7UpSTK17ASerine/threonine kinase 17aNM_004760
201912_s_at2.6UpGSPT1G1 to S phase transition 1NM_002094
202887_s_at2.6DownDDIT4DNA-damage-inducible transcript 4NM_019058
202687_s_at2.9UpTNFSF10Tumor necrosis factor (ligand) superfamily, member 10NM_003810
202411_at3.1UpIFI27Interferon, alpha-inducible protein 27NM_005532
202391_at3.1UpBASP1Brain abundant, membrane-attached signal protein 1NM_006317

Cell proliferation208676_s_at1.5UpPA2G4Proliferation-associated 2G4, 38 kDaU87954
205937_at1.5UpCGREF1Cell growth regulator with EF-hand domain 1NM_006569
1773_at1.5DownFNTBFarnesyltransferase, CAAX box, betaL00635
202886_s_at2.2UpPPP2R1BProtein phosphatase 2, regulatory subunit A, beta isoformM65254
202167_s_at1.9DownMMS19MMS19 nucleotide excision repair homolog NM_022362
203108_at2.1UpGPRC5AG protein-coupled receptor, family C, group 5, member ANM_003979
202454_s_at2.7DownERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 NM_001982

204798_at1.6UpMYBv-myb myeloblastosis viral oncogene homolog NM_005375
218717_s_at1.7UpLEPREL1Leprecan-like 1NM_018192
209765_at1.8UpADAM19ADAM metallopeptidase domain 19 AF311317
202381_at1.8UpADAM9ADAM metallopeptidase domain 9NM_003816
203044_at2.1UpCHSY1Chondroitin sulfate synthase 1NM_014918
Extracellular matrix 205479_s_at2.1UpPLAUPlasminogen activator, urokinaseNM_002658
210845_s_at2.1UpPLAURPlasminogen activator, urokinase receptorU08839
201995_at2.2UpEXT1Exostoses (multiple) 1NM_000127
205828_at3.4UpMMP3Matrix metallopeptidase 3 (stromelysin 1)NM_002422
203936_s_at2.2UpMMP9Matrix metallopeptidase 9 NM_004994
202620_s_at2.4UpPLOD2Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2NM_000935
207316_at2.8UpHAS1hyaluronan synthase 1NM_001523
203343_at3.2UpUGDHUDP-glucose dehydrogenaseNM_003359
204620_s_at4.0UpVCANVersicanNM_004385
202766_s_at5.6UpFBN1Fibrillin 1NM_000138
202404_s_at4.1UpCOL1A2Collagen, type I, alpha 2NM_000089
201852_x_at2.9UpCOL3A1Collagen, type III, alpha 1 NM_000090
211980_at2.4UpCOL4A1Collagen, type IV, alpha 1NM_001845
221730_at2.7UpCOL5A2Collagen, type V, alpha 2NM_000393
207134_x_at2.2UpTPSB2Tryptase beta 2NM_024164
210084_x_at2.1UpTPSAB1Tryptase alpha/beta 1AF206665
214533_at3.5UpCMA1Chymase 1, mast cellNM_001836
205624_at2.1UpCPA3Carboxypeptidase A3 (mast cell)NM_001870
206871_at3.3UpELA2Elastase 2, neutrophilNM_001972
205653_at5.0UpCTSGCathepsin GNM_001911
202376_at1.7DownSERPINA3Serpin peptidase inhibitor, clade A, member 3NM_001085
201147_s_at1.8DownTIMP3TIMP metallopeptidase inhibitor 3NM_000362
206243_at2.8DownTIMP4TIMP metallopeptidase inhibitor 4NM_003256

Dermal-epidermal junction216971_s_at1.5DownPLEC1Plectin 1, intermediate filament binding proteinZ54367
214292_at1.5DownITGB4Integrin, beta 4AA808063
210150_s_at1.5DownLAMA5Laminin, alpha 5BC003355

Metabolism
207786_at1.9DownCYP2R1Cytochrome P450, family 2, subfamily R, polypeptide 1NM_024514
211019_s_at2.1DownLSS2,3-oxidosqualene-lanosterol cyclaseD63807
205676_at2.5UpCYP27B1Cytochrome P450, family 27, subfamily B, polypeptide 1NM_000785