Reevaluating the Concept of Treating Experimental Tumors with a Mixed Bacterial Vaccine: Coley’s Toxin

Table 1

Cell cycle distribution of tumor control cells and following CT treatment.

MIA PaCa-2

T3M4

BxPc-3

AsPC-1

Phase

0

0.05 * 10^4

0.25 * 10^4

25 * 10^5

0

0.05 * 10^4

0.25 * 10^4

25 * 10^5

0

0.05 * 10^4

0.25 * 10^4

25 * 10^5

0

0.05 * 10^4

0.25 * 10^4

25 * 10^5

cfu/mL

cfu/mL

cfu/mL

cfu/mL

G0/G1

48.7±9.4

48.6±13.9

43.1±13.0

43.6±0.7

77.5±1.1

76.7±3.5

67.4±3.8

64.5±2.2

44.7±8.5

43.0±1.0

31.8±4.1

36.6±9.9

48.1±10.1

52.7±6.8

37.5±8.9

30.7±3.6

S

33.4±9.5

36.5±10.4

43.1±12.7

50.5±6.2

18.0±0.9

18.2±4.5

28.7±5.1

31.1±1.5

24.1±5.5

44.8±7.1

68.0±4.4^∗

63.1±7.9^∗

39.5±11.3

34.3±11.5

58.9±9.7

67.9±3.1^#

G2/M

17.9±3.9

15.6±3.4

13.8±0.9

8.5±5.5

4.6±0.3

5.1±1.2

4.0±1.3

4.4±0.7

31.2±3.2

8.8±5.0^∗

0.4±0.4^∗

0.3±0.2^#

16.7±5.9

13.0±5.3

0.4±0.4^#

0.4±0.1^#

Data show percentage values of tumor cells (% positive cells) following 24 hours of treatment. Experiments were at least three times repeated. Values of are given as mean ± SEM; *P < 0.05 versus control; t-test. ^#P < 0.05 versus control; U-test.