Table of Contents Author Guidelines Submit a Manuscript
Clinical and Developmental Immunology
Volume 2012, Article ID 239368, 9 pages
http://dx.doi.org/10.1155/2012/239368
Review Article

A Key Role for NF-κB Transcription Factor c-Rel in T-Lymphocyte-Differentiation and Effector Functions

1Institute for Medical Microbiology and Hygiene, Philipps University of Marburg, Hans Meerwein Straße 2, 35032 Marburg, Germany
2Department of Immunology, Max Planck Institute of Infection Biology, 10117 Berlin, Germany

Received 8 October 2011; Revised 13 December 2011; Accepted 31 December 2011

Academic Editor: Niels Olsen Saraiva Camara

Copyright © 2012 Alexander Visekruna et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [22 citations]

The following is the list of published articles that have cited the current article.

  • Jiin-Tarng Liou, Chiou-Mei Lee, Yi-Chiao Lin, Chun-Yu Chen, Chia-Chih Liao, Hung-Chen Lee, and Yuan-Ji Day, “P-selectin is required for neutrophils and macrophage infiltration into injured site and contributes to generation of behavioral hypersensitivity following peripheral nerve injury in mice,” Pain, 2013. View at Publisher · View at Google Scholar
  • Sheng-Ning Zhang, Jiang-Hua Ran, Jing Liu, Zhu Li, Lai-Bang Li, Yang Gao, Xi-Bing Zhang, Shu-Yuan Wu, and Li Li, “Expression of nuclear factor-kappa B p65 in acute rejection of liver transplantation in rhesus monkey,” Chinese Journal of Tissue Engineering Research, vol. 17, no. 31, pp. 5581–5587, 2013. View at Publisher · View at Google Scholar
  • Oliver Planz, “Development of cellular signaling pathway inhibitors as new antivirals against influenza,” Antiviral Research, vol. 98, no. 3, pp. 457–468, 2013. View at Publisher · View at Google Scholar
  • Galliano Zanello, Ashleigh Goethel, Katharina Forster, Kaoru Geddes, Dana J. Philpott, and Kenneth Croitoru, “Nod2 Activates NF-kB in CD4(+) T Cells but Its Expression Is Dispensable for T Cell-Induced Colitis,” Plos One, vol. 8, no. 12, 2013. View at Publisher · View at Google Scholar
  • A Visekruna, T Linnerz, V Martinic, N Vachharajani, S Hartmann, H Harb, T Joeris, P I Pfefferle, M J Hofer, and U Steinhoff, “Transcription factor c-Rel plays a crucial role in driving anti-CD40-mediated innate colitis,” Mucosal Immunology, 2014. View at Publisher · View at Google Scholar
  • Yusuke Shono, Andrea Z. Tuckett, Samedy Ouk, Hsiou-Chi Liou, Gregoire Altan-Bonnet, Jennifer J. Tsai, Jennifer E. Oyler, Odette M. Smith, Mallory L. West, Natalie V. Singer, Ekaterina Doubrovina, Dmitry Pankov, Chandresh V. Undhad, George F. Murphy, Cecilia Lezcano, Chen Liu, Richard J. O'Reilly, and Marcel R. M. van den Brink, “A Small-Molecule c-Rel Inhibitor Reduces Alloactivation of T Cells without Compromising Antitumor Activity,” Cancer Discovery, vol. 4, no. 5, pp. 578–591, 2014. View at Publisher · View at Google Scholar
  • Teresa Laguna, Laura Notario, Raffaella Pippa, Miguel G. Fontela, Berta N. Vázquez, Miren Maicas, Noemí Aguilera-Montilla, Ángel L. Corbí, María D. Odero, and Pilar Lauzurica, “New insights on the transcriptional regulation of CD69 gene through a potent enhancer located in the conserved non-coding sequence 2,” Molecular Immunology, vol. 66, no. 2, pp. 171–179, 2015. View at Publisher · View at Google Scholar
  • Katherine M. Ottolini, Clesson E. Turner, and Satyen M. Gada, “Hypogammaglobulinemia and impaired antibody response in a child with chromosome 2p15-16.1 microdeletion syndrome,” Annals of Allergy, Asthma & Immunology, 2015. View at Publisher · View at Google Scholar
  • Huang Yuxian, Chen Xintong, Cai Songhao, Long Hui, Guo Kunyuan, Wu Bingyi, Song Chaoyang, He Yanjie, and Li Yuhua, “The inhibitory effect of siRNA silencing NF-kB gene family members on the expressions of NKG2DLs on human hepatocellular carcinoma HepG2 cells,” Chinese Journal of Cancer Biotherapy, vol. 22, no. 6, pp. 696–702, 2015. View at Publisher · View at Google Scholar
  • Yan Wang, Aijuan Qu, and Hua Wang, “Signal Transducer and Activator of Transcription 4 in Liver Diseases,” International Journal Of Biological Sciences, vol. 11, no. 4, pp. 448–455, 2015. View at Publisher · View at Google Scholar
  • Vibe Skov, Mark Burton, Mads Thomassen, Thomas Stauffer Larsen, Caroline H. Riley, Ann Brinch Madelung, Lasse Kjær, Henrik Bondo, Inger Stamp, Mats Ehinger, Rasmus Dahl-Sørensen, Nana Brochmann, Karsten Nielsen, Jürgen Thiele, Morten K. Jensen, Ole Weis Bjerrum, Torben A. Kruse, and Hans Carl Hasselbalch, “A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis,” Plos One, vol. 11, no. 8, pp. e0161570, 2016. View at Publisher · View at Google Scholar
  • Eugen Feist, Gerd-Rüdiger Burmester, and Elke Krüger, “The Proteasome - Victim or Culprit in Autoimmunity,” Clinical Immunology, 2016. View at Publisher · View at Google Scholar
  • Sajjad Molavi Pordanjani, and Seyed Jalal Hosseinimehr, “The role of NF-κB inhibitors in cell response to radiation,” Current Medicinal Chemistry, vol. 23, no. 34, pp. 3951–3963, 2016. View at Publisher · View at Google Scholar
  • Yao-Zhong Liu, Pooja Maney, Jyoti Puri, Yu Zhou, Melody Baddoo, Michael Strong, Yu-Ping Wang, Erik Flemington, and Hong-Wen Deng, “RNA-sequencing study of peripheral blood monocytes in chronic periodontitis,” Gene, 2016. View at Publisher · View at Google Scholar
  • Yusuke Shono, Andrea Z. Tuckett, Hsiou-Chi Liou, Ekaterina Doubrovina, Enrico Derenzini, Samedy Ouk, Jennifer J. Tsai, Odette M. Smith, Emily R. Levy, Fabiana M. Kreines, Carly G. K. Ziegler, Mary I. Scallion, Mikhail Doubrovin, Glenn Heller, Anas Younes, Richard J. O'Reilly, Marcel R. M. van den Brink, and Johannes L. Zakrzewski, “Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-kappa B-Controlled Oxidative Stre,” Cancer Research, vol. 76, no. 2, pp. 377–389, 2016. View at Publisher · View at Google Scholar
  • Jingming Liu, Wei Wang, Joy Fleming, Lijun Bi, Mengqiu Gao, and Chuanyou Li, “Identifying key regulator genes for tuberculosis by differential co-expression analysis of gene expression profiling,” Current Bioinformatics, vol. 12, no. 2, pp. 185–192, 2017. View at Publisher · View at Google Scholar
  • Hongling Zhang, Jiacheng Bi, Huqiang Yi, Tingting Fan, Qingguo Ruan, Lintao Cai, Youhai H Chen, and Xiaochun Wan, “Silencing c-Rel in macrophages dampens Th1 and Th17 immune responses and alleviates experimental autoimmune encephalomyelitis in mice,” Immunology and Cell Biology, 2017. View at Publisher · View at Google Scholar
  • Minghua Hu, Xianyu Yuan, Yangming Liu, Shunsheng Tang, Jinglei Miao, Qiliang Zhou, and Shijie Chen, “IL-1β-induced NF-κB activation down-regulates miR-506 expression to promotes osteosarcoma cell growth through JAG1,” Biomedicine & Pharmacotherapy, vol. 95, pp. 1147–1155, 2017. View at Publisher · View at Google Scholar
  • Jun Li, Keke Zhang, Xingyi Hua, Wenjie Dai, Yixing Cui, Yihui Bi, Tao You, Yapeng Zhu, Mingkai Zhang, Zheng Fang, and Jian Zhou, “Effect of Shikonin on Spinal Cord Injury in Rats Via Regulation of HMGB1/TLR4/NF-κB Signaling Pathway,” Cellular Physiology and Biochemistry, vol. 43, no. 2, pp. 481–491, 2017. View at Publisher · View at Google Scholar
  • Junfeng Liu, Rong Hua, Zhangbin Gong, Bin Shang, Yongyi Huang, Lihe Guo, Te Liu, and Jun Xue, “Human amniotic epithelial cells inhibit CD4+ T cell activation in acute kidney injury patients by influencing the miR-101-c-Rel-IL-2 pathway,” Molecular Immunology, vol. 81, pp. 76–84, 2017. View at Publisher · View at Google Scholar
  • Shirin Fallahi, Seyede Momeneh Mohammadi, Hamid Tayefi Nasrabadi, Alireza Alihemmati, Naser Samadi, Sanaz Gholami, Dariush Shanehbandi, and Hojjatollah Nozad Charoudeh, “Impact of C-rel inhibition of cord blood-derived B-, T-, and NK cells,” Journal of Immunotoxicology, pp. 1–8, 2017. View at Publisher · View at Google Scholar
  • Wei Zhang, Yanxia Lu, Xiaomin Li, Jianming Zhang, Lin Zheng, Wenjuan Zhang, Chun Lin, Weihao Lin, and Xuenong Li, “CDCA3 promotes cell proliferation by activating the NF-κB/cyclin D1 signaling pathway in colorectal cancer,” Biochemical and Biophysical Research Communications, 2018. View at Publisher · View at Google Scholar