Association between IL17 Polymorphisms and Risk of Cervical Cancer in Chinese Women
Table 2
Analysis of patient characteristics and polymorphism of locus rs2275913.
Characteristics
Total number
Genotype
P value
Allele
P value
OR (95% CI)
AA
AG
GG
A
G
Age
≤45 year
200
51 (25.5)
95 (47.5)
54 (27.0)
0.324
197 (49.3)
203 (50.7)
0.184
1.25 (0.90–1.74)
>45 year
111
25 (22.5)
47 (42.4)
39 (35.1)
97 (43.7)
125 (56.3)
Clinical stage
I
135
20 (14.8)
73 (54.1)
42 (31.1)
Ref
113 (41.9)
157 (58.1)
Ref
1.46 (1.06–2.01) 2.03 (0.69–6.04)
II
169
53 (31.4)
67 (39.6)
49 (29.0)
0.002
173 (51.2)
165 (48.8)
0.022
III
7
3 (42.8)
2 (28.6)
2 (28.6)
0.198
8 (57.1)
6 (42.9)
0.193
Tumor differentiation
Poor
251
59 (23.5)
118 (47.0)
74 (29.5)
0.588
236 (47.0)
266 (53.0)
0.795
0.95 (0.64–1.41)
Well-moderate
60
17 (28.3)
24 (40.0)
19 (31.7)
58 (48.3)
62 (51.7)
Lymph node status
Positive
55
20 (36.4)
20 (36.4)
15 (27.2)
0.070
60 (54.5)
50 (45.5)
0.092
0.70 (0.46–1.06)
Negative
256
56 (21.9)
122 (47.6)
78 (30.5)
234 (45.7)
278 (54.3)
Parametrial invasion
Positive
95
24 (25.3)
48 (50.5)
23 (24.2)
0.328
96 (50.5)
94 (49.5)
0.280
1.21 (0.86–1.70)
Negative
216
52 (24.1)
94 (43.5)
70 (32.4)
198 (45.8)
234 (54.2)
Peritumor intravascular cancer emboli
Positive
121
43 (35.5)
45 (37.2)
33 (27.3)
0.001
131 (54.1)
111 (45.9)
0.006
1.57 (1.14–2.71)
Negative
190
33 (17.4)
97 (51.1)
60 (31.6)
163 (42.9)
217 (57.1)
corresponds to the number of individuals. Adjusted by age, clinical stage, tumor differentiation, lymph node status, parametrial invasion, and peritumor intravascular cancer emboli. Poor: undifferentiated cell with a spindle shape and presence of nuclear fission; moderate: individual cell keratinization but no cellular bridge or keratin pearl formation; well: differentiated cells with keratin pearl. Boldfaced values indicate a significant difference at the 5% level.
