Persistence of Diarrheal Pathogens Is Associated with Continued Recruitment of Plasmablasts in the Circulation
Numbers of vaccine antigen (O9,12)-specific circulating plasmablasts identified as antibody-secreting cells/106 PBMC (IgA- + IgG- + IgM) in six volunteers vaccinated with the live oral Salmonella typhi Ty21a vaccine. Each volunteer received one vaccine dose on days 0, 2, and 4 (the vaccination days are indicated with “+”). To determine the kinetics of the response, the numbers of plasmablasts were determined on several days for as long as ASCs were found in the samples. The values of each individual are connected with a line.
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