Enhanced HMGB1 Expression May Contribute to Th17 Cells Activation in Rheumatoid Arthritis

Figure 3

FACS analyzed the CD3⁺CD8^-IL-17⁺ cell ratio in RA patient The PBMCs were isolated by standard Ficoll-Hypaque density centrifugation. The cells were stained by anti-CD3-PE-cy5, anti-CD8-FITC, and anti-IL-17-PE. (a) First figure presented CD3⁺CD8^-T cells were considered CD4⁺T cells in region RL, and the other three were presented healthy controls. (b) Representative IL-17 expression in CD3⁺CD8^-T subsets from RA patients in inactive phase. (c) Representative IL-17 expression in CD3⁺CD8^-T subsets from RA patients in active phase. (d) The results were shown as means ± SD. * 𝑃<0.05 compared with the control group.

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