Table of Contents Author Guidelines Submit a Manuscript
Clinical and Developmental Immunology
Volume 2012 (2012), Article ID 308237, 9 pages
http://dx.doi.org/10.1155/2012/308237
Research Article

The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population

1Department of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China
2Department of Blood Transfusion, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China
3Department of Infectious Disease, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710032, China
4Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China

Received 26 July 2012; Accepted 5 September 2012

Academic Editor: Christina Spiropoulou

Copyright © 2012 Ying Ma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. S. Schmaljohn, S. E. Hasty, J. M. Dalrymple et al., “Antigenic and genetic properties of viruses linked to hemorrhagic fever with renal syndrome,” Science, vol. 227, no. 4690, pp. 1041–1044, 1985. View at Google Scholar · View at Scopus
  2. C. S. Schmaljohn and J. M. Dalrymple, “Analysis of Hantaan virus RNA: evidence for a new genus of Bunyaviridae,” Virology, vol. 131, no. 2, pp. 482–491, 1983. View at Google Scholar · View at Scopus
  3. C. Ma, P. Yu, M. Nawaz et al., “Hantaviruses in rodents and humans, Xi'an, PR China,” Journal of General Virology, vol. 93, no. 10, pp. 2227–2236, 2012. View at Google Scholar
  4. Y. Z. Zhang, Y. Zou, Z. F. Fu, and A. Plyusnin, “Hantavirus infections in humans and animals, China,” Emerging Infectious Diseases, vol. 16, no. 8, pp. 1195–1203, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. U. Shankarkumar, B. Sridharan, and R. M. Pitchappan, “HLA diversity among Nadars, a primitive Dravidian caste of South India,” Tissue Antigens, vol. 62, no. 6, pp. 542–547, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Ivanova, E. Rozemuller, N. Tyufekchiev, A. Michailova, M. Tilanus, and E. Naumova, “HLA polymorphism in Bulgarians defined by high-resolution typing methods in comparison with other populations,” Tissue Antigens, vol. 60, no. 6, pp. 496–504, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. P. Sánchez-Velasco, N. S. Karadsheh, A. García-Martín, C. Ruíz de Alegría, and F. Leyva-Cobián, “Molecular analysis of HLA allelic frequencies and haplotypes in Jordanians and comparison with other related populations,” Human Immunology, vol. 62, no. 9, pp. 901–909, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. U. C. Chaturvedi, R. Nagar, and R. Shrivastava, “Dengue and dengue haemorrhagic fever: implications of host genetics,” FEMS Immunology and Medical Microbiology, vol. 47, no. 2, pp. 155–166, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Appanna, S. Ponnampalavanar, L. L. Chai See, and S. D. Sekaran, “Susceptible and protective HLA Class 1 alleles against dengue fever and dengue hemorrhagic fever patients in a Malaysian population,” PLoS One, vol. 5, no. 9, Article ID e13029, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Lobigs, A. Müllbacher, and M. Regner, “MHC class I up-regulation by flaviviruses: immune interaction with unknown advantage to host or pathogen,” Immunology and Cell Biology, vol. 81, no. 3, pp. 217–223, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. R. Yossef, B. Rosental, M. Y. Appel, O. Hershkovitz, and A. Porgador, “Upregulation of MHC class I expression following dengue virus infection: the mechanism at the promoter level,” Expert Review of Anti-Infective Therapy, vol. 10, no. 3, pp. 285–287, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Othman, N. A. Rahman, and R. Yusof, “Induction of MHC Class I HLA-A2 promoter by dengue virus occurs at the NFkappaB binding domains of the Class I Regulatory Complex,” Virus Research, vol. 163, no. 1, pp. 238–245, 2012. View at Publisher · View at Google Scholar
  13. A. Said, W. Azab, A. Damiani, and N. Osterrieder, “Equine herpesvirus Type 4 UL56 and UL49. 5 proteins downregulate cell surface major histocompatibility complex class I expression independently of each other,” Journal of Virology, vol. 86, no. 15, pp. 8059–8071, 2012. View at Publisher · View at Google Scholar
  14. V. M. Noriega, J. Hesse, T. J. Gardner, K. Besold, B. Plachter, and D. Tortorella, “Human cytomegalovirus US3 modulates destruction of MHC class I molecules,” Molecular Immunology, vol. 51, no. 2, pp. 245–253, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Mäkelä, J. Mustonen, I. Ala-Houhala et al., “Human leukocyte antigen-B8-DR3 is a more important risk factor for severe Puumala hantavirus infection than the tumor necrosis factor-α(-308) G/A polymorphism,” Journal of Infectious Diseases, vol. 186, no. 6, pp. 843–846, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. J. Mustonen, J. Partanen, M. Kanerva et al., “Association of HLA B27 with benign clinical course of nephropathia epidemica caused by Puumala hantavirus,” Scandinavian Journal of Immunology, vol. 47, no. 3, pp. 277–279, 1998. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Korva, A. Saksida, S. Kunilo, B. V. Jeras, and T. Avšič-Županc, “HLA-associated hemorrhagic fever with renal syndrome disease progression in Slovenian patients,” Clinical and Vaccine Immunology, vol. 18, no. 9, pp. 1435–1440, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. E. D. Kilpatrick, M. Terajima, F. T. Koster, M. D. Catalina, J. Cruz, and F. A. Ennis, “Role of specific CD8+ T cells in the severity of a fulminant zoonotic viral hemorrhagic fever, hantavirus pulmonary syndrome,” Journal of Immunology, vol. 172, no. 5, pp. 3297–3304, 2004. View at Google Scholar · View at Scopus
  19. C. P. Ferrer, P. A. Vial, M. M. Ferrés et al., “Genetic susceptibility to Andes Hantavirus: association between severity of disease and HLA alleles in Chilean patients,” Revista Chilena de Infectologia, vol. 24, no. 5, pp. 351–359, 2007. View at Google Scholar · View at Scopus
  20. T. P. Nguyen, M. Kikuchi, T. Q. Vu et al., “Protective and enhancing HLA alleles, HLA-DRB1*0901 and HLA-A*24, for severe forms of dengue virus infection, dengue hemorrhagic fever and dengue shock syndrome,” PLoS Neglected Tropical Diseases, vol. 2, no. 10, p. e304, 2008. View at Google Scholar · View at Scopus
  21. H. Loke, D. B. Bethell, C. X. T. Phuong et al., “Strong HLA class I-restricted T cell responses in dengue hemorrhagic fever: a double-edged sword?” Journal of Infectious Diseases, vol. 184, no. 11, pp. 1369–1373, 2001. View at Publisher · View at Google Scholar · View at Scopus
  22. M. L. Wang, J. H. Lai, Y. Zhu et al., “Genetic susceptibility to haemorrhagic fever with renal syndrome caused by Hantaan virus in Chinese Han population,” International Journal of Immunogenetics, vol. 36, no. 4, pp. 227–229, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Wang, J. Wang, Y. Zhu et al., “Cellular immune response to hantaan virus nucleocapsid protein in the acute phase of hemorrhagic fever with renal syndrome: correlation with disease severity,” Journal of Infectious Diseases, vol. 199, no. 2, pp. 188–195, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Waghray, D. Keppler, B. F. Sloane, L. Schuger, and Y. Q. Chen, “Analysis of a truncated form of cathepsin H in human prostate tumor cells,” Journal of Biological Chemistry, vol. 277, no. 13, pp. 11533–11538, 2002. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Tang and A. Bansal, “Protocol for analyzing human leukocyte antigen variants and sexually transmitted infections: from genotyping to immunoassays,” Methods in Molecular Biology, vol. 903, pp. 359–380, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. C. Shen, B. Zhu, M. Liu, and S. Li, “Genetic polymorphisms at HLA-A, -B, and -DRB1 loci in Han population of Xi'an City in China,” Croatian Medical Journal, vol. 49, no. 4, pp. 476–482, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. C. M. Shen, B. F. Zhu, S. H. Ye et al., “Allelic diversity and haplotype structure of HLA loci in the Chinese Han population living in the Guanzhong region of the Shaanxi province,” Human Immunology, vol. 71, no. 6, pp. 627–633, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. T. Hautala, S. M. Mhnen, T. Sironen et al., “Central nervous system-related symptoms and findings are common in acute Puumala hantavirus infection,” Annals of Medicine, vol. 42, no. 5, pp. 344–351, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Mustonen, J. Partanen, M. Kanerva et al., “Genetic susceptibility to severe course of nephropathia epidemica caused by Puumala hantavirus,” Kidney International, vol. 49, no. 1, pp. 217–221, 1996. View at Google Scholar · View at Scopus
  30. J. Mustonen, N. P. Huttunen, J. Partanen et al., “Human leukocyte antigens B8-DRB1*03 in pediatric patients with nephropathia epidemica caused by Puumala hantavirus,” Pediatric Infectious Disease Journal, vol. 23, no. 10, pp. 959–961, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. L. Cebalo, T. Dušek, I. Kuzman, and A. Markotić, “Grading of disease severity in patients with Puumala or Dobrava virus infection in Croatia during the 1995–2000 period,” Acta Medica Croatica, vol. 57, no. 5, pp. 355–359, 2003. View at Google Scholar · View at Scopus
  32. T. Tuuminen, E. Kekäläinen, S. Mäkelä et al., “Human CD8+ T cell memory generation in Puumala hantavirus infection occurs after the acute phase and is associated with boosting of EBV-specific CD8+ memory T cells,” Journal of Immunology, vol. 179, no. 3, pp. 1988–1995, 2007. View at Google Scholar · View at Scopus
  33. H. L. van Epps, M. Terajima, J. Mustonen et al., “Long-lived memory T lymphocyte responses after hantavirus infection,” Journal of Experimental Medicine, vol. 196, no. 5, pp. 579–588, 2002. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Caillat-Zucman, “Molecular mechanisms of HLA association with autoimmune diseases,” Tissue Antigens, vol. 73, no. 1, pp. 1–8, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. C. D. Hammerbeck and J. W. Hooper, “T Cells are not required for pathogenesis in the Syrian hamster model of hantavirus pulmonary syndrome,” Journal of Virology, vol. 85, no. 19, pp. 9929–9944, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. L. Yan, L. Q. Fang, H. G. Huang et al., “Landscape elements and Hantaan virus-related hemorrhagic fever with renal syndrome, People's Republic of China,” Emerging Infectious Diseases, vol. 13, no. 9, pp. 1301–1306, 2007. View at Google Scholar · View at Scopus