Journal of Immunology Research

Research Article

The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population

Table 3

Comparison of the phenotype frequencies of major alleles of HLA-A, -B, and -DRB1 in hemorrhagic fever with renal syndrome population and control group.


Phenotype	HFRS	Controls	Fold of frequency		Pc	OR (95% CI)
Phenotype	AF (%)	AF (%)	Fold of frequency		Pc	OR (95% CI)

HLA-B*46	24.32	14.86	1.64	0.045	0.540	1.84 (1.01–3.37)
HLA-DRB1*12	12.50	24.05	0.52	0.031	0.310	0.45 (0.22–0.94)
HLA-DRB1*09	38.89	22.70	1.71	0.004	0.040	2.17 (1.27–3.69)

The alleles were selected for a frequency >5% and the value < 0.05. value derived from Pearson Chi-square test; HFRS: hemorrhagic fever with renal syndrome; OR: odds ratio; CI: confidence interval; AF: allele frequency in percentage.
The frequencies of the following alleles are not significant different between HFRS and controls: HLA-A*02, *11, *31, *30, *33, *32, *01, *24, *03; HLA-B*13, *40, *15, *58, *51, *07, *44, *35, *54, *48, *52; HLA-DRB1*07, *04, *11, *15, *14, *08, *03, *13.