The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population

Table 4

Comparison of the haplotype frequencies in hemorrhagic fever with renal syndrome population and control group.

Haplotypes	HFRS patients	Controls	Fold of frequency	𝑃	OR (95% CI)
	AF (%)	AF (%)
HLA-B*46-DRB1*09	15.49	7.84	1.98	0.040	2.16 (1.02–4.55)
HLA-B*51-DRB1*09	5.63	1.62	3.47	0.037	3.62 (1.00–13.18)

The haplotypes were selected for a frequency >5% in either patients group or control group and the 𝑃 value < 0.05. 𝑃 value derived from Pearson Chi-square test; HFRS: hemorrhagic fever with renal syndrome; OR: odds ratio; CI: confidence interval; AF: allele frequency in percentage.
The frequencies of the following haplotypes are not significant different between HFRS and Controls: A*02-B*46, A*30-B*13, A*33-B*58, A*02-B*51, A*02-B*13, A*11-B*13, B*13-DRB1*07, B*13-DRB1*12, B*52-DRB1*15, B*13-DRB1*15, A*30-B*13-DRB1*07, A*02-B*46-DRB1*09.