DNA Methyltransferase 3B Gene Promoter and Interleukin-1 Receptor Antagonist Polymorphisms in Childhood Immune Thrombocytopenia

Table 3

Distribution of allele and genotype frequencies of IL-1 Ra VNTR polymorphism in children with ITP and controls.

	ITP children; 𝑛=32 (%)	Controls; 𝑛=64 (%)	OR	95% CI	P value
Genotype frequency					0.295
I/I	16 (50)	44 (68.75)	0.40^#	0.15–0.98
I/II	14 (43.75)	15 (23.44)	2.54^§	1.03–6.30	0.043^*#
			2.60^#	1.02–6.50
II/II	2 (6.25)	2 (3.13)
III/III	0 (0)	0 (0)
I/III	0 (0)	1 (1.56)
I/IV	0 (0)	1 (1.56)
II/IV	0 (0)	1 (1.56)
Allelic frequency ^†					0.042*
Allele I	46 (71.9)	103 (84.43)	0.47	0.23–0.98
Allele II	18 (28.1)	19 (15.57)	2.12	1.02–4.41

^*𝑃<0.05.
 ^†Alleles from genotypes I/I, I/II, and II/II.
^#Genotype I/I versus genotype I/II.
^§Genotype I/II versus all genotypes.