Characterization of Outer Membrane Vesicles from Brucella melitensis and Protection Induced in Mice
Electron microscopy of OMVs from smooth B. melitensis M16 and rough B. melitensis VTRM1. Negative stain of OMVs released from surface B. melitensis VTRM1 (a) and B. melitensis 16 M (b); negative stain of OMV purified by differential centrifugation from both strains; B. melitensis VTRM1 (c) and B. melitensis 16 M (d). The arrows point to the apparent shedding of the OMVs from the cell surface in (a) and (b); while the arrows in (c) and (d) point to spherical OMVs purified from both strains. The bars correspond to 100 nm.
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