Journal of Immunology Research

Research Article

Maternal Plasma Phosphatidylcholine Fatty Acids and Atopy and Wheeze in the Offspring at Age of 6 Years

Table 5

Relative risks (RR) for the association between standardised values (-scores) of maternal plasma PC fatty acids and persistent/late wheeze with and without atopy.


	Persistent/late wheeze with atopy						Persistent/late wheeze without atopy
Maternal exposure	Unadjusted analysis			Adjusted* analysis			Unadjusted analysis			Adjusted^† analysis
	RR	(95% CI)		RR	(95% CI)		RR	(95% CI)		RR	(95% CI)

Total -3 PUFAs %	0.8	(0.62, 1.02)	0.07	0.72	(0.54, 0.96)	0.03	0.62	(0.46, 0.84)	0.002	0.69	(0.51, 0.95)	0.021
ALA %	1.07	(0.80, 1.42)	0.65	0.91	(0.70, 1.19)	0.49	1.11	(0.84, 1.49)	0.46	1.17	(0.87, 1.58)	0.30
DHA %	0.79	(0.59, 1.05)	0.11	0.74	(0.55, 1.00)	0.05	0.59	(0.44, 0.81)	0.0009	0.67	(0.49, 0.93)	0.015
EPA %	0.74	(0.54, 1.01)	0.06	0.65	(0.43, 0.98)	0.04	0.61	(0.41, 0.92)	0.017	0.57	(0.37, 0.89)	0.014
Total -6 PUFAs %	1.12	(0.88, 1.43)	0.35	1.05	(0.79, 1.39)	0.75	1.12	(0.86, 1.45)	0.40	1.00	(0.76, 1.30)	0.97
LA %	0.99	(0.76, 1.29)	0.94	0.88	(0.65, 1.20)	0.42	1.22	(0.92, 1.61)	0.18	1.17	(0.88, 1.54)	0.28
AA %	0.99	(0.78, 1.24)	0.90	1.06	(0.82, 1.36)	0.66	0.82	(0.65, 1.03)	0.08	0.76	(0.60, 0.96)	0.023
Total -3 : -6 PUFAs ratio	0.78	(0.60, 1.00)	0.05	0.73	(0.54, 0.99)	0.04	0.64	(0.46, 0.87)	0.005	0.73	(0.53, 0.99)	0.05
ALA: unsaturated metabolic products	1.22	(0.94, 1.59)	0.14	1.07	(0.85, 1.34)	0.58	1.43	(1.12, 1.82)	0.005	1.46	(1.10, 1.95)	0.010
LA: unsaturated metabolic products	0.88	(0.69, 1.12)	0.29	0.78	(0.59, 1.04)	0.09	1.14	(0.93, 1.40)	0.20	1.19	(0.97, 1.48)	0.10

Children with persistent/late wheeze with and without atopy were compared to children without atopy who had never wheezed. Unadjusted and adjusted analyses for each maternal variable are presented.
RR: relative risk; ALA: alpha-linolenic acid; DHA: docosahexaenoic acid; EPA: eicosapentaenoic acid; LA: linoleic acid; AA: arachidonic acid. RR derived from Poisson regression.
*Adjusted for maternal asthma and atopy, paternal asthma, child’s sex, and dogs/cats in the home during the child’s infancy.
^†Adjusted for maternal asthma, paternal asthma, maternal smoking during pregnancy, and dogs/cats in the home during the child’s infancy.