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Clinical and Developmental Immunology
Volume 2012 (2012), Article ID 483935, 5 pages
http://dx.doi.org/10.1155/2012/483935
Clinical Study

Serum Cytokine Profile by ELISA in Patients with Echinococcal Cysts of the Liver: A Stage-Specific Approach to Assess Their Biological Activity

Luca Piccoli,1 Valeria Meroni,2 Francesca Genco,2 Francesca Tamarozzi,1 Carmine Tinelli,3 Carlo Filice,1 and Enrico Brunetti1

1Department of Infectious Diseases, IRCCS San Matteo Hospital Foundation, University of Pavia, and WHO Collaborating Centre for Clinical Management of Cystic Echinococcosis, Pavia 27100, Italy
2Laboratory of Parasitology, Department of Infectious Diseases, IRCCS San Matteo Hospital Foundation, University of Pavia, Pavia 27100, Italy
3Clinical Epidemiology and Biometric Unit, IRCCS San Matteo Hospital Foundation, Pavia 27100, Italy

Received 10 August 2011; Revised 18 October 2011; Accepted 19 October 2011

Academic Editor: Georgios Pappas

Copyright © 2012 Luca Piccoli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Brunetti, P. Kern, and D. A. Vuitton, “Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans,” Acta Tropica, vol. 114, no. 1, pp. 1–16, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. Z. Galitza, E. Bazarsky, R. Sneier, J. Peiser, and J. El-On, “Repeated treatment of cystic echinococcosis in patients with a long-term immunological response after successful surgical cyst removal,” Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 100, no. 2, pp. 126–133, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. M. P. Zarzosa, A. O. Domingo, P. Gutierrez et al., “Evaluation of six serological tests in diagnosis and postoperative control of pulmonary hydatid disease patients,” Diagnostic Microbiology and Infectious Disease, vol. 35, no. 4, pp. 255–262, 1999. View at Publisher · View at Google Scholar
  4. W. Hosch, T. Junghanss, M. Stojkovic et al., “Metabolic viability assessment of cystic echinococcosis using high-field 1H MRS of cyst contents,” NMR in Biomedicine, vol. 21, no. 7, pp. 734–754, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. N. B. Nouir, C. Gianinazzi, M. Gorcii et al., “Isolation and molecular characterization of recombinant Echinococcus granulosus P29 protein (recP29) and its assessment for the post-surgical serological follow-up of human cystic echinococcosis in young patients,” Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 103, no. 4, pp. 355–364, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Hernández-González, A. Muro, I. Barrera, G. Ramos, A. Orduña, and M. Siles-Lucas, “Usefulness of four different Echinococcus granulosus recombinant antigens for serodiagnosis of unilocular hydatid disease (UHD) and postsurgical follow-up of patients treated for UHD,” Clinical and Vaccine Immunology, vol. 15, no. 1, pp. 147–153, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Riganò, B. Buttari, E. de Falco et al., “Echinococcus granulosus-specific T-cell lines derived from patients at various clinical stages of cystic echinococcosis,” Parasite Immunology, vol. 26, no. 1, pp. 45–52, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. R. Rigano, E. Profumo, F. Bruschi et al., “Modulation of human immune response by Echinococcus granulosus antigen B and its possible role in evading host defenses,” Infection and Immunity, vol. 69, no. 1, pp. 288–296, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Siracusano, R. Riganò, E. Ortona et al., “Immunomodulatory mechanisms during Echinococcus granulosus infection,” Experimental Parasitology, vol. 119, no. 4, pp. 483–489, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Rigano, B. Buttari, E. Profumo et al., “Echinococcus granulosus antigen B impairs human dendritic cell differentiation and polarizes immature dendritic cell maturation towards a Th2 cell response,” Infection and Immunity, vol. 75, no. 4, pp. 1667–1678, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. R. Rigano, E. Profumo, S. Ioppolo, S. Notargiacomo, A. Teggi, and A. Siracusano, “Serum cytokine detection in the clinical follow up of patients with cystic echinococcosis,” Clinical and Experimental Immunology, vol. 115, no. 3, pp. 503–507, 1999. View at Publisher · View at Google Scholar · View at Scopus
  12. M. R. Bayraktar, N. Mehmet, and R. Durmaz, “Th1 and Th2 inducing cytokines in Cystic echinococcosis,” Turkiye parazitolojii dergisi Turkiye Parazitoloji Dernegi Acta parasitologica Turcica, vol. 29, no. 3, pp. 167–170, 2005. View at Google Scholar
  13. D. Mezioug and C. Touil-Boukoffa, “[Cytokine profile in human hydatidosis: possible role in the immunosurveillance of patients infected with Echinococcus granulosus],” Parasite, vol. 16, no. 1, pp. 57–64, 2009. View at Google Scholar · View at Scopus
  14. F. Tamarozzi, V. Meroni, F. Genco et al., “Ex vivo assessment of serum cytokines in patients with cystic echinococcosis of the liver,” Parasite Immunology, vol. 32, no. 9-10, pp. 696–700, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. E. Brunetti and T. Junghanss, “Update on cystic hydatid disease,” Current Opinion in Infectious Diseases, vol. 22, no. 5, pp. 497–502, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. WHO-IWGE, “International classification of ultrasound images in cystic echinococcosis for application in clinical and field epidemiological settings,” Acta Tropica, vol. 85, no. 2, pp. 253–261, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. T. Junghanss, A. M. da Silva, J. Horton, P. L. Chiodini, and E. Brunetti, “Clinical management of cystic echinococcosis: state of the art, problems, and perspectives,” American Journal of Tropical Medicine and Hygiene, vol. 79, no. 3, pp. 301–311, 2008. View at Google Scholar · View at Scopus
  18. R. Rigano, E. Profumo, G. di Felice, E. Ortona, A. Teggi, and A. Siracusano, “In vitro production of cytokines by peripheral blood mononuclear cells from hydatic patients,” Clinical and Experimental Immunology, vol. 99, no. 3, pp. 433–439, 1995. View at Google Scholar · View at Scopus
  19. R. Rigano, E. Profumo, S. Ioppolo, S. Notargiacomo, A. Teggi, and A. Siracusano, “Cytokine patterns in seropositive and seronegative patients with Echinococcus granulosus infection,” Immunology Letters, vol. 64, no. 1, pp. 5–8, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. R. Rigano, E. Profumo, B. Buttari, A. Teggi, and A. Siracusano, “Cytokine gene expression in peripheral blood mononuclear cells (PBMC) from patients with pharmacologically treated cystic echinococcosis,” Clinical and Experimental Immunology, vol. 118, no. 1, pp. 95–101, 1999. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Torcal, M. Navarro-Zorraquino, R. Lozano et al., “Immune response and in vivo production of cytokines in patients with liver hydatidosis,” Clinical and Experimental Immunology, vol. 106, no. 2, pp. 317–322, 1996. View at Google Scholar · View at Scopus
  22. W. Zhang, A. G. Ross, and D. P. McManus, “Mechanisms of immunity in hydatid disease: implications for vaccine development,” Journal of Immunology, vol. 181, no. 10, pp. 6679–6685, 2008. View at Google Scholar · View at Scopus
  23. A. Diaz, C. Casaravilla, J. E. Allen, R. B. Sim, and A. M. Ferreira, “Understanding the laminated layer of larval Echinococcus II: immunology,” Trends in Parasitology, vol. 27, no. 6, pp. 264–273, 2011. View at Publisher · View at Google Scholar
  24. X. Zhou, M. S. Fragala, J. E. McElhaney, and G. A. Kuchel, “Conceptual and methodological issues relevant to cytokine and inflammatory marker measurements in clinical research,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 13, no. 5, pp. 541–547, 2010. View at Publisher · View at Google Scholar · View at Scopus