CD154: An Immunoinflammatory Mediator in Systemic Lupus Erythematosus and Rheumatoid Arthritis

<table>Structural and functional characteristics of CD154 receptors. Four receptors for CD154 have been identified, namely, CD40, <i>α</i>IIb<i>β</i>3, <i>α</i>5<i>β</i>1, and <i>α</i>M<i>β</i>2. These receptors are found on various cell types and induce different biological functions upon CD154 binding. APC: antigen presenting cells, DC: dendritic cells, MC: monocyte, EC: endothelial cell, FB: fibroblast, SMC: smooth muscle cell, Mac: macrophage, ICAM: intercellular adhesion molecule, GPIb<i>α</i>: glycoprotein Ib<i>α</i>, JAM-3: junctional adhesion molecule-3, MPO: myeloperoxidase.</table>

Journal of Immunology Research

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Figure 2: CD154: An Immunoinflammatory Mediator in Systemic Lupus Erythematosus and Rheumatoid Arthritis 