Figure 3: T lymphocyte profile in the lamina propria of small and large intestine of IL-10−/− mice during the course of intestinal inflammation. Lamina propria T cells from small and large intestine were obtained from either 6- or 16-week-old IL-10−/− mice. Age-matched 129Sv/Ev (WT) mice were used as controls. Frequencies of CD4+CD44+ (a), CD4+CD69+ (b), CD4+CD25+Foxp3+ (c), and CD4+CD25+LAP+ (d) T cells gated in CD4+ T cells were assessed by flow cytometry. Bars represent the mean ± SEM of 4 mice per group. Significant differences (* , ** or *** ) are indicated by asterisks.