CD4 T-Cell-Independent Antibody Response Reduces Enterovirus 71 Lethality in Mice by Decreasing Tissue Viral Loads

Figure 1

Infection of mice with EV71. (a) The survival rates of wild-type mice (WT; 𝑛=8), CD4^−/− mice (𝑛=9), and B^−/− mice (𝑛=11) infected with 8×10⁶ PFU/mouse of EV71 are shown. (b) The survival rates of wild-type mice (WT; 𝑛=12), CD4^−/− mice (𝑛=13), and B^−/− mice (𝑛=13) infected with 4×10⁵ PFU/mouse of EV71 are shown. Survival rates that are significantly different by the log-rank test are indicated as follows: ^∗∗𝑃<0.01; ^∗∗∗𝑃<0.001.

(a)

(b)