Restoration of Innate and Adaptive Immune Responses by HCV Viral Inhibition with an Induction Approach Using Natural Interferon-Beta in Chronic Hepatitis C
Table 2
Baseline characteristics of chronic hepatitis C patients with genotype 1 and high viral loads treated with the NCT and the SOC.
Patient no.
Age/gender
Body weight (kg)
BMI (kg/m2)
Liver histology (stage/grade)
HCV-RNA (TaqMan PCR Log lU/mL)
ALT (IU/mL)
Hb (g/dL)
Platelet (104/mL)
Outcome
NCT
1
61/F
48.5
20.9
A1/F1
5.9
38
12.1
17.7
SVR
2
61/F
46.1
20.4
A1/F1
6.2
197
9.2
17.5
SVR
3
47/M
67.0
21.1
A1/F1
5.9
37
14.8
14.3
SVR
4
49/M
60.0
19.8
A2/F1
6.6
50
15.0
22.0
SVR
5
66/M
78.0
24.5
A2/F3
5.8
19
15.7
9.6
SVR
6
40/F
73.0
27.1
A2/F1
7.7
48
13.8
39.1
TVR
7
58/F
55.0
20.6
−/−
6.4
32
12.6
17.7
TVR
8
73/M
53.4
21.0
A1/F1
6.4
20
12.1
22.4
SVR
SOC
1
62/M
61.0
19.7
A2/F3
6.1
65
14.2
9.6
NVR
2
56/M
61.3
19.6
A2/F2
6.8
96
16.0
16.4
TVR
3
69/F
48.2
21.4
A2/F2
7.4
54
12.0
12.9
NVR
4
54/M
77.9
24.0
−/−
6.8
79
15.8
7.9
NVR
5
64/M
71.4
25.0
A3/F2
7.3
273
14.2
13.9
SVR
6
69/F
58.1
23.9
A1/F1
5.7
31
15.7
13.4
TVR
7
56/M
75.7
24.4
−/−
6.5
63
14.0
22.4
SVR
8
51/M
49.5
16.5
A1/F0
6.1
56
13.2
18.2
SVR
NCT: novel combination treatment; cyclic and periodic IFN treatment (CPIT) consisting of induction treatment with natural interferon-β followed by maintenance treatment with natural interferon-α for 24 wks as induction approach followed by SOC for 48 wks, SOC: Standard of care; Standard of care; ribavirin plus pegylated interferon α 2b for 48 wks, SVR: sustained virologic response, NVR: No Virological Response, TVR: Transient Virological Response.
