Evaluating Frequency, Diagnostic Quality, and Cost of Lyme Borreliosis Testing in Germany: A Retrospective Model Analysis
Table 1
German LB proficiency testing program: characteristics of selected serum samples as determined by the reference laboratories of the BISSGG.
Sample
PHA
EIA (poly valent)
IFA- IgG
IFA- IgM
EIA- IgG
EIA- IgM
CLIA- IgG
CLIA IgM
Line blot
Immuno-blot IgG
Immuno-blot IgM
Clinical information (time of sampling after therapy)
31/2006
N (<80)
N
N (<40)
N (<20)
N
N
N
N
N
N
N
Syphilis stage I (4 yrs)
32/2006
P (1280)
P
P (320)
B/P (20)
P
B/P
P
B/P
P
P
B/P
Recent Lyme arthritis (1 yr)
61/2006
N (<80)
N
N (<40)
N (<20)
N
N
N
N
N
N
N
Healthy blood donor
62/2006
P (320)
P
B/P (80)
P (320)
B/P
P
P
P
P
B/P
P
Morbus Bannwarth (1.5 mo)
21/2007
P (160)
B/P
B/P (80)
N/B/P (≤40)
B/P
N/B/P
B/P
N/B/P
B/P
B/P
B/P
Seropositive but asymptomatic donor, several tick bites in recent medical history
22/2007
N (<80)
N
N (<40)
N (<20)
N
N
N
N
N
N
N
Healthy blood donor
61/2007
N (<80)
N
N (<40)
N (<20)
N
N
N
N
N
N
N
Syphilis stage II (8 weeks after treatment)
62/2007
P (1280)
P
P (320)
N (<20)
P
N
P
N
P
P
N/B
Seropositive but asymptomatic donor, several tick bites in recent medical history
31/2008
N (<80)
N
N (<40)
N (<20)
N
N
N
N
N
N
N
Healthy blood donor
32/2008
P (320)
P
P (160)
P (80)
P
P
P
P
P
P
P
Morbus Bannwarth, CSF pleocytosis, specific CSF antibody index (AI): 6.3
61/2008
P (1280)
P
P (160)
N/B (≤20)
P
N
P
N
P
P
N
Lymphocytoma (2 mo)
62/2008
N (<80)
N
N (<40)
N (<20)
N
N
N
N
N
N
N
Healthy blood donor
*Legend: P, positive, B, borderline, and N, negative. For some samples, combinations (i.e., N & B, B & P, or N/B/P) were accepted. Median titers as determined by the reference laboratories are given in parentheses.
