Frequent Detection of Anti-Tubercular-Glycolipid-IgG and -IgA Antibodies in Healthcare Workers with Latent Tuberculosis Infection in the Philippines
Table 2
Comparison between QFT-positive and QFT-negative HCWs and HIV-AC.
Variables
HCWs
HIV-AC
QFT+ ()
QFT− ()
QFT+ ()
QFT− ()
Age; median (range)
45 (21~62)
23.5 (19~48)
0.002*
25 (19~45)
31 (21~35)
0.036*
Gender: male; (%)
7 (46.6)
9 (47.4)
0.43
12 (92.3)
42 (97.67)
0.43
Work duration->10 yrs; (%)
11(73.3)
6 (37.5)
0.098
NA
NA
NA
CD4+ count (/μL); median (range)
ND
ND
NA
611 (148~1466)
356 (13~1125)
0.012*
TBGL-IgG positive; (%)
11 (73)
5 (31)
0.02*
8 (61.5)
25 (58.13)
0.545
TBGL-IgA positive; (%)
5 (33)
1 (6)
0.072
3 (23)
13 (30)
0.415
TBGL-IgG+IgA positive; (%)
4 (27)
0 (0)
0.043*
2(15.4)
10 (23.3)
0.42
IFN-γ-nc (IU/mL)†
0.9
0.0087*
Serum IgG (mg/dL)†
0.2
0.5
Serum IgA (mg/dL)†
0.32
0.68
OPN (ng/mL)†
0.87
0.43
Leptin (ng/mL)†
0.25
0.24
Abbreviations: HCWs, healthcare workers; HIV-AC, newly diagnosed cases of asymptomatic human immune-deficiency virus infection; OPN, osteopontin; ND, not determined; NA, not applicable. †mean ± SD; IFN-γ-nc: levels of IFN-γ, measured in the nonstimulated QFT-plasma samples; values for statistical differences between QFT-positive and QTF-negative groups; *significant differences ().