TY - JOUR A2 - Sansonno, Domenico AU - De Re, Valli AU - Caggiari, Laura AU - Garziera, Marica AU - De Zorzi, Mariangela AU - Repetto, Ombretta PY - 2012 DA - 2012/08/16 TI - Molecular Signature in HCV-Positive Lymphomas SP - 623465 VL - 2012 AB - Hepatitis C virus (HCV) is a positive, single-stranded RNA virus, which has been associated to different subtypes of B-cell non-Hodgkin lymphoma (B-NHL). Cumulative evidence suggests an HCV-related antigen driven process in the B-NHL development. The underlying molecular signature associated to HCV-related B-NHL has to date remained obscure. In this review, we discuss the recent developments in this field with a special mention to different sets of genes whose expression is associated with BCR coupled to Blys signaling which in turn was found to be linked to B-cell maturation stages and NF-κb transcription factor. Even if recent progress on HCV-B-NHL signature has been made, the precise relationship between HCV and lymphoma development and phenotype signature remain to be clarified. SN - 2314-8861 UR - https://doi.org/10.1155/2012/623465 DO - 10.1155/2012/623465 JF - Clinical and Developmental Immunology PB - Hindawi Publishing Corporation KW - ER -