Regulatory T Cells Accumulate in the Lung Allergic Inflammation and Efficiently Suppress T-Cell Proliferation but Not Th2 Cytokine Production
Oral tolerance prevents airway allergic disease. (a) Respiratory pattern to increasing dose of methacholine (MCh) in control, allergic, or tolerant BALB/c mice 24 h after the last OVA challenge. (b) BAL differential cell counts. Quantification by ELISA of (c) IL-5, (d) IL-13 in the BAL fluid, and (e) anti-OVA IgE, (f) IgG1 in the serum. (g) Histology of lung sections at 100x. Lung parenchyma inflammation and mucus production by goblet cells are shown in representative lung sections stained with hematoxylin/PAS. Values represent the means ± SEM for groups of five mice and are representative of more than three experiments. Significant differences *, **, and *** are shown.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.