Regulatory T Cells Accumulate in the Lung Allergic Inflammation and Efficiently Suppress T-Cell Proliferation but Not Th2 Cytokine Production
Regulatory T cells are not the major producer of suppressive cytokines in the BAL. Quantification by ELISA of BAL (a) IL-10, (b) total, and (c) bioactive TGF-β of BALB/c control, allergic and tolerant mice upon 24 h of the last OVA challenge. (d) IL-10, LAP, and IL-5 staining of BAL CD4+Foxp3+ cells from allergic mice. Pooled cells recovered from BAL of five allergic mice were stained for CD4, Foxp3, IL-10, LAP, and IL-5 and gated in CD4-positive cells. Values represent the means ± SEM for groups of five mice and are representative of two experiments. Significant differences *, *** are shown.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.