Clinical Study
Diminished Expression of Complement Regulatory Proteins on Peripheral Blood Cells from Systemic Lupus Erythematosus Patients
Table 1
Demographic, clinical, and laboratory features of SLE patients.
| | Patients’ features | SLE () | Healthy controls () |
| | Females (%) | 93 | 67.2 | | Age (year) median (interquartile range) | 42 (31–53) | 45 (30–61) | | SLEDAIa median (interquartile range) | 2 (0–5) | — | | SLICC-DIb median (interquartile range) | 1 (0–2) | — | | Malar rash (%) | 58 | — | | Nephritis (%) | 45 | — | | Arthritis (%) | 67 | — | | AIHAc (%) | 28 | — | | RBC (×1012 cells/uL) | 4.15 (0.55)d | 4.4 (0.36) | | Hemoglobin (g/dL) | 12.0 (1.6)d | 13.5 (1.2) | | Platelets (×103 cells/uL) | 208 (65)d | 228 (45) | | Leucocytes (×103 cells/uL) | 5.43 (4.07–7.91)e | 6.96 (6–8.59) | | Lymphocytes (×103 cells/uL) | 1.32 (0.85–1.79)e | 2.25 (1.75–2.85) | | Neutrophils (×103 cells/uL) | 3.58 (2.22–5.29)e | 3.77 (3.08–4.74) | | Monocytes (×103 cells/uL) | 0.48 (0.37–0.68)e | 0.58 (0.6–0.75) | | Thrombocytopenia* (%) | 16 | 0 | | Leukopenia* (%) | 17 | 0 | | Lymphopenia* (%) | 38 | 0 | | Neutropenia* (%) | 13 | 0 | | Anemia* (%) | 21 | 0 | | C4 level | 25.4 (16.8) | — | | C3 level | 108.4 (28.1) | — |
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aSLEDAI: systemic lupus erythematosus disease activity index.
bSLICC-DI: systemic lupus international collaborating clinics damage index.
cAIHA: autoimmune hemolytic anemia (positive Coombs’ test).
dMean ± SD.
eMedian (interquartile range).
*Lymphopenia: <1200 lymphocytes/uL, neutropenia: <1500 neutrophils/uL, anemia: hemoglobin < 11 g/dL, and thrombocytopenia: platelets < 150.000 cells/uL.
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