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Clinical and Developmental Immunology
Volume 2012, Article ID 728480, 10 pages
Review Article

Recurrent Herpetic Stromal Keratitis in Mice: A Model for Studying Human HSK

1Department of Ophthalmology, Saint Louis University School of Medicine, 1402 S. Grand Blvd., Schwitalla Hall, Room M99, St. Louis, MO 63104-1004, USA
2Department of Biology, Washington University School of Medicine, St. Louis, MO 63104, USA

Received 16 December 2011; Revised 20 February 2012; Accepted 20 February 2012

Academic Editor: Lbachir BenMohamed

Copyright © 2012 Patrick M. Stuart and Tammie L. Keadle. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Herpes simplex virus 1 (HSV-1) infection of the cornea leads to a potentially blinding disease, termed herpetic stromal keratitis (HSK) that is characterized by lesions of an immunoinflammatory nature. In spite of the fact that HSK typically presents as a recurrent disease due to reactivation of virus which latently infects the trigeminal ganglia, most murine studies of HSK have employed a primary and not recurrent model of the disease. This report documents the several recurrent models of HSK that have been developed and how data generated from these models differs in some important aspects from data generated following primary infection of the cornea. Chief among these differences is the fact that recurrent HSK takes place in the context of an animal that has a preexisting anti-HSV immune response, while primary HSK occurs in an animal that is developing such a response. We will document both differences and similarities that derive from this fundamental difference in these models with an eye towards possible vaccines and therapies that demonstrate promise in treating HSK.