Identification of RD5-Encoded Mycobacterium tuberculosis Proteins As B-Cell Antigens Used for Serodiagnosis of Tuberculosis

Table 2

Sensitivities and specificities for IgG antibodies against RD5-encoded M. tuberculosis proteins.

		Sensitivity			Sensitivity
	Smear-positive TB (𝑛=48)	Smear-negative TB (𝑛=12)	All TB patients (𝑛=60)	BCG-vaccinated healthy control (𝑛=12)	PPD^− healthy control (𝑛=20)	All healthy control (𝑛=32)
ESAT-6^a	25.0% (12/48)	8.4% (1/12)	21.7% (13/60)	83.4% (10/12)	95.0% (19/20)	90.6% (29/32)
Rv3117^a	25.0% (12/48)	25.0% (3/12)	25.0% (15/60)	91.7% (11/12)	100.0% (20/20)	96.9% (31/32)
Rv3118^a	12.5% (6/48)	8.4% (1/12)	11.7% (7/60)	91.7% (11/12)	90.0% (18/20)	90.6% (29/32)
Rv3119^a	10.4% (5/48)	16.7% (2/12)	11.7% (7/60)	91.7% (11/12)	100% (20/20)	96.9% (31/32)
Rv3120^a	29.2% (14/48)	41.7% (5/12)	31.7% (19/60)	91.7% (11/12)	100.0% (20/20)	96.9% (31/32)
Rv3121^a	4.2% (2/48)	8.4% (1/12)	5.0% (3/60)	91.7% (11/12)	85.5% (17/20)	87.5% (28/32)
Rv3117 + Rv3120^b	33.3% (16/48)	41.7% (5/12)	35.0% (21/60)	91.7% (11/12)	100.0% (20/20)	96.9% (31/32)

^aThe cut-off value was calculated from the mean OD value plus three standard deviations (SDs) for healthy controls.
^bThe serum tested was determined to be TB positive according to the criteria as follows: any antigen specifically reacts with serum when the cut-off value was calculated from the mean OD plus three standard deviations.