Table of Contents Author Guidelines Submit a Manuscript
Clinical and Developmental Immunology
Volume 2012, Article ID 762541, 15 pages
Review Article

Review on Autoimmune Reactions in Female Infertility: Antibodies to Follicle Stimulating Hormone

1Department of Immunology, Institute of General and Molecular Pathology, University of Tartu, Ravila Street 19, Biomedicum, Tartu 50411, Estonia
2Department of Obstetrics and Gynecology, University of Tartu, L. Puusepa 8, 51014 Tartu, Estonia
3Competence Centre on Reproductive Medicine and Biology, Tiigi 61b, Tartu 50410, Estonia

Received 27 May 2011; Accepted 3 August 2011

Academic Editor: Gilbert Faure

Copyright © 2012 Kadri Haller-Kikkatalo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Female fertility can be affected by diseases or dysfunctions of reproductive tract, neuroendocrine system, and immune system. Reproductive autoimmune failure can be associated with overall activation of immune system or with immune system reactions specifically directed against ovarian antigens. Majority of the antiovarian autoantibodies are directed against β-subunit of follicle stimulating hormone (anti-FSH). This paper summarizes a current clinical classification of female infertility in the context of general activation of autoimmunity and antiovarian autoimmunity by describing serum anti-FSH. The presence of naturally occurring anti-FSH in healthy women will be discussed. In addition, the putative impairment of ovarian folliculogenesis in case of increased production of those antibodies in infertile women will be characterized.