Immunogenetic Factors Associated with Severe Respiratory Illness Caused by Zoonotic H1N1 and H5N1 Influenza Viruses

Table 1

Genetic polymorphisms of interest in H1N1 susceptibility and severity.

Gene	Polymorphism	Functional significance	Reference
CCR5	CCR5∆32	Increased allele frequency among Canadian H1N1 ICU cases	[25]
FcγRIIa, IGHG2	IGHG2 *n/*-n; FcγRIIa-R131H	Polymorphisms previously linked to IgG2 deficiency, but not corroborated in H1N1 patients	[28–30]
NLRP3	2107C/A (Q705 K); rs4612666 (intron 7); rs10754558 (3′ UTR)	Association with dysregulation of inflammatory response (2107), alteration of NLRP3 mRNA stability and enhancer activity	[33, 34]
HLA	Various alleles	Influenza-specific CTL responses exhibit varying frequency and magnitude across various HLA alleles	[35]