Journal of Immunology Research / 2012 / Article / Tab 1

Research Article

Adaptive Immunity in Ankylosing Spondylitis: Phenotype and Functional Alterations of T-Cells before and during Infliximab Therapy

Table 1

Prevalence and ratios of T-cell subsets in ankylosing spondylitis patients before and during infliximab (IFX) therapy.

Members of adaptive immunityHealthy controls Before IFX therapy Week 2 after IFX therapy Week 6 after IFX therapy

CD4+35.80 [29.43-40.95]42.7 [38.35–48.65]*47.10 [43.00–49.10]*44.30 [42.15–48.85]*
CD4+CD45RA+49.50 [40.68–61.68]50.80 [45.20–65.95]50.90 [36.20–55.40]#42.55 [39.55–60.78]#
CD4+CD25+7.55 [6.20–7.88]4.82 [4.22–5.42]*3.92 [3.60–4.85]*4.35 [4.04–4.98]*
CD4+CD69+3.23 [2.83–4.48]3.05 [2.72–3.28]3.04 [2.69–3.43]2.88 [2.21–3.36]
CD4+HLA-DR+2.8 [2.53–3.81]3.03 [2.09–3.46]1.95 [1.56–2.33]2.89 [2.21–3.51]
CD4+CD45RO+42.95 [33.33–49.65]41.50 [29.40–49.55]45.50 [37.80–54.60]47.45 [33.10–54.78]#

Th19.81 [8.95–12.53]12.90 [11.75–13.80]*14.00 [11.50–15.70]*13.80 [12.43–18.83]*
Th24.54 [4.19–4.84]9.18 [7.32–11.45]*8.70 [7.98–11.30]*10.90 [8.32–12.50]*
Th1/Th2 ratio2.38 [1.95–2.64]1.31 [1.06–1.85]*1.40 [1.16–1.83]*1.38 [1.11–1.72]*
Th170.69 [0.60–0.77]1.18 [1.02–1.69]*1.2 [0.84–1.55]*1.26 [0.91–1.51]*
Treg4.42 [3.76–5.58]4.45 [3.57–5.51]4.29 [3.66–5.72]4.42 [4.05–5.24]
Th17/Treg ratio0.14 [0.13–0.21]0.27 [0.19–0.45]*0.25 [0.17–0.39]*0.29 [0.18–0.37]*

CD8+18.00 [14.35–27.98]17.70 [14.65–21.45]18.30 [14.20–21.90]16.65 [14.43–21.60]
CD8+CD45RA+62.85 [53.38–75.78]70.30 [61.70–78.75]69.10 [55.20–72.50]60.20 [54.43–70.33]
CD8+CD25+2.84 [1.87–4.06]2.81 [2.23–3.63]2.85 [2.07–3.23]3.29 [1.84–3.54]
CD8+CD69+4.0 [3.53–12.78]4.88 [3.37–5.89]3.71 [3.26–6.77]5.06 [3.55–6.27]
CD8+HLA-DR+3.58 [3.10–5.31]3.43 [2.95–4.33]4.37 [2.93–5.15]3.57 [2.91–5.15]
CD8+CD45RO+23.65 [15.90–28.15]19.40 [14.25–28.20]26.30 [19.10–34.90]28.45 [18.53–40.20]
CD4/CD8 ratio2.07 [1.32–2.83]2.26 [2.02–3.15]2.61 [1.99–3.21]2.82 [1.90–3.36]

Data are expressed as median [interquartile range] *versus control ; #versus before IFX .

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