Journal of Immunology Research / 2012 / Article / Tab 3

Research Article

Characterization of Chronic Cutaneous Lesions from TNF-Receptor-1-Deficient Mice Infected by Leishmania major

Table 3

Comparison between human mucocutaneous and TNFR1 KO lesions.

CharacteristicMucocutaneous leishmaniasisL. major-infected TNFR1 KO

Chronic cutaneous lesionsYesYes
Intense inflammatory cells infiltrate in chronic phaseYesYes
Low parasite load in lesionsYesYes
High production of proinflammatory cytokines (IFN-γ and TNF-α) in the lesionsYesYes
Defect in the regulation of inflammatory responseYesYes
Presence of high numbers of CD8+ T cells and neutrophils in lesionsYesYes
High levels of IL-17YesNot determined
Invasion of mucosal tissuesYesNo

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