Research Article
Characterization of Chronic Cutaneous Lesions from TNF-Receptor-1-Deficient Mice Infected by Leishmania major
Table 3
Comparison between human mucocutaneous and TNFR1 KO lesions.
| Characteristic | Mucocutaneous leishmaniasis | L. major-infected TNFR1 KO |
| Chronic cutaneous lesions | Yes | Yes | Intense inflammatory cells infiltrate in chronic phase | Yes | Yes | Low parasite load in lesions | Yes | Yes | High production of proinflammatory cytokines (IFN-γ and TNF-α) in the lesions | Yes | Yes | Defect in the regulation of inflammatory response | Yes | Yes | Presence of high numbers of CD8+ T cells and neutrophils in lesions | Yes | Yes | High levels of IL-17 | Yes | Not determined | Invasion of mucosal tissues | Yes | No |
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