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Clinical and Developmental Immunology
Volume 2012 (2012), Article ID 868251, 7 pages
Review Article

Autoantibodies to Apolipoprotein A-1 in Cardiovascular Diseases: Current Perspectives

1Translational Research Sciences, F.n Hoffman-La Roche Ltd., 4070 Basel, Switzerland
2Department of Human Protein Science, Geneva Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland
3Division of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Geneva University Hospital Geneva, 1211 Geneva, Switzerland
4Laboratory Medicine Service, Department of Genetics and Laboratory Medicine, Geneva University Hospital, 4 Rue Gabrielle-Perret-Gentil, 1211 Geneva, Switzerland

Received 2 October 2012; Accepted 19 October 2012

Academic Editor: Dimitrios P. Bogdanos

Copyright © 2012 P. C. Teixeira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Immune-mediated inflammation plays a major role in atherosclerosis and atherothrombosis, two essential features for cardiovascular disease (CVD) development, currently considered as the leading cause of death in the western world. There is accumulating evidence showing that humoral autoimmunity might play an important role in CVD and that some autoantibodies could represent emerging cardiovascular risk factors. Recent studies demonstrate that IgG autoantibodies against apolipoprotein A-1 (apoA-1) are raised in many diseases associated with a high cardiovascular risk, such as systemic lupus erythematosus, acute coronary syndrome, rheumatoid arthritis, severe carotid stenosis, and end-stage renal disease. In this work, we aimed at reviewing current data in the literature pointing to anti-apolipoprotein A-1 antibodies (anti-apoA-1 IgG) as a possible prognostic and diagnostic biomarker of cardiovascular risk and appraising their potential role as active mediators of atherogenesis.