Association between Functional Polymorphisms of Foxp3 Gene and the Occurrence of Unexplained Recurrent Spontaneous Abortion in a Chinese Han Population
Table 2
Genotype and allele frequencies of the four Foxp3 polymorphisms in controls and URSA patients together with case-control analysis.
Marker
Genotype allele
URSA N (%)
Controls N (%)
value
P value
OR (95% CI)
rs2294021
C/C
65 (44.50)
40 (35.70)
T/C
70 (47.90)
57 (50.90)
T/T
11 (7.60)
15 (13.40)
3.480
C/C
65 (44.50)
40 (35.70)
T/C + T/T
81 (55.50)
72 (64.30)
2.037
T/C
70 (47.90)
57 (50.09)
C/C + T/T
76 (52.10)
55 (49.10)
0.220
T/T
11 (7.60)
15 (13.40)
C/C + T/C
135 (92.40)
97 (86.60)
2.401
rs5902434
ATT/ATT
11 (7.53)
14 (12.50)
del/ATT
62 (42.47)
56 (50.00)
del/del
73 (50.0)
42 (37.50)
4.620
ATT/ATT
11 (7.53)
14 (12.50)
del/ATT + del/del
135 (92.47)
98 (87.50)
1.786
del/ATT
62 (42.47)
56 (50.00)
del/del + ATT/ATT
84 (57.53)
56 (50.00)
1.450
del/del
73 (50.0)
42 (37.50)
del/ATT + ATT/ATT
73 (50.00)
70 (62.50)
4.008
0.60 (0.36, 0.99)
rs2232365
A/A
8 (5.48)
17 (15.18)
8.320
1
A/G
70 (47.94)
56 (50.00)
4.640
2.66 (1.07, 6.61)
G/G
68 (46.58)
39 (34.82)
8.260
3.71 (1.47, 9.37)
A/G
70 (47.94)
56 (50.00)
A/A + G/G
76 (52.06)
56 (50.00)
0.107
G/G
68 (46.58)
39 (34.82)
A/A + A/G
78 (53.42)
73 (65.18)
3.607
A/A
8 (5.48)
17 (15.18)
A/G + G/G
138 (94.52)
95 (84.82)
6.810
3.09 (1.28, 7.44)
rs3761548
C/C
15 (10.27)
25 (22.32)
8.280
1
A/C
56 (38.36)
45 (40.18)
1.690
1.44 (0.83, 2.47)
A/A
75 (51.37)
42 (37.50)
8.620
2.98 (1.42, 6.26)
A/C
56 (38.36)
45 (40.18)
C/C + A/A
90 (61.64)
67 (59.82)
0.088
A/A
75 (51.37)
42 (37.50)
C/C + A/C
71 (48.63)
70 (62.50)
4.920
0.57 (0.34, 0.94)
C/C
15 (10.27)
25 (22.32)
A/C + A/A
131 (89.73)
87 (77.68)
7.020
2.51 (1.25, 5.03)
rs2294021
C
200 (68.50)
137 (61.20)
T
92 (31.50)
87 (38.80)
3.01
1.38 (0.96, 1.99)
rs5902434
ATT
84 (28.77)
84 (37.50)
del
208 (71.23)
140 (62.50)
4.40
1.49 (1.03, 2.15)
rs2232365
A
86 (29.45)
90 (40.18)
G
206 (70.55)
134 (59.82)
6.50
1.61 (1.11, 2.32)
rs3761548
C
86 (29.45)
95 (42.40)
A
206 (70.55)
129 (57.60)
8.37
1.73 (1.20, 2.50)
was determined by Pearson’s Chi-square test for contingency tables. , was determined by Pearson’s Chi-square test for contingency tables. ,, are considered statistically significant.
