Association between Functional Polymorphisms of Foxp3 Gene and the Occurrence of Unexplained Recurrent Spontaneous Abortion in a Chinese Han Population

Table 3

Eight three-locus Foxp3 promoter region haplotypes identified in URSA group and the control group and their estimated frequencies using the software HAPLOVIEW (version 4.2).

Allele			Haplotype frequency (N, %)
rs5902434	rs3761548	rs2232365	URSA	Control	χ ^2 value	P	OR (95% CI)
del	C	A	6 (2.1)	8 (3.4)	0.824	0.36
del	A	G	187 (64.1)	93 (41.6)	25.86	0.000	2.51 (1.75.3.58)
del	C	G	9 ( 3.2)	35 (15.8)	25.39	0.000	0.18 (0.08, 0.37)
del	A	A	5 (1.8)	4 (1.7)	0.013	0.91
ATT	A	G	4 (1.3)	2 (0.7)	0.387	0.53
ATT	A	A	10 (3.3)	30 (13.5)	18.6	0.000	0.22 (0.10, 0.46)
ATT	C	G	6 (1.9)	4 (1.6)	0.05	0.82
ATT	C	A	65 (22.3)	48 (21.6)	0.033	0.86