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Clinical and Developmental Immunology
Volume 2012 (2012), Article ID 914162, 4 pages
http://dx.doi.org/10.1155/2012/914162
Review Article

Recent Advances in Dermatitis Herpetiformis

Department of Dermatology, Kochi Medical School, Kochi University, Kohasu, Okocho, Nankoku, Kochi 783-8505, Japan

Received 12 February 2012; Accepted 5 June 2012

Academic Editor: Marzia Caproni

Copyright © 2012 Kimiko Nakajima. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Dermatitis herpetiformis is an autoimmune bullous disease that is associated with gluten sensitivity which typically presents as celiac disease. As both conditions are multifactorial disorders, it is not clear how specific pathogenetic mechanisms may lead to the dysregulation of immune responses in the skin and small bowel, respectively. Recent studies have demonstrated that IgA and antibodies against epidermal transglutaminase 3 play an important role in the pathogenesis of dermatitis herpetiformis. Here, we review recent immunopathological progress in understanding the pathogenesis of dermatitis herpetiformis.