Figure 1: Influence of distinct cytokine milieu in the differentiation of CD4+T cells. Blue arrows show the differentiation of naïve cells in the presence of particular cytokines. The green arrows represent the self-amplification phase by the encircled cytokines. Plasticity of T cell subset under the influence of specific cytokine is represented by the red arrows. Along with Th subset, the master regulator is shown. However, Bcl6 has not yet been identified as the master regulator, but it plays major role in the differentiation of Tfh.