Molecular Networks Involved in the Immune Control of BK Polyomavirus
Table 1
Demographics and transplant related variables.
CG ()
BKVN ()
AV ()
value
At baseline
Recipient age (years)
50 ± 10
44 ± 21
47 ± 10
ns
Donor age (years)
49.2 ± 13
47 ± 18
46 ± 15
ns
Living donor (n, %)
1/9%
3/30%
1/22%
ns
Gender (male, %)
6/54%
3/30%
6/66%
ns
HLA mismatches
3 ± 1
4 ± 1
2 ± 1
ns
Peak level of PRA
5 ± 7
44 ± 40
1 ± 1
ns
CMV serostatus
D−/R−
1/9%
1/10%
1/11%
ns
D−/R+
1/9%
1/10%
1/11%
ns
D+/R−
3/27%
1/10%
1/11%
ns
D+/R+
6/54%
7/70%
6/66%
ns
Dialysis before TX (months)
19 ± 10
27 ± 15
32 ± 26
ns
At 3M biopsy
Time after TX
94.8 ± 5.8
343 ± 268
85.6 ± 13.5
ns
BMI (kg/m2)
23.5 ± 4.8
27.3 ± 4.3
27.2 ± 4.7
ns
Immunosuppression
Induction
36%
50%
44%
ns
Tacrolimus
73%
80%
89%
ns
Cyclosporin A
27%
0%
0
ns
mTOR
18%
40%
11%
ns
Mycophenolate mofetil
55%
70%
89%
ns
Prednisone
73%
90%
89%
ns
CIT (deceased donor)
20 ± 3
13 ± 9
19 ± 3
ns
Serum creatinine (μmol/L)
112 ± 60.3
210 ± 67.2
126 ± 35.3
**
Serum creatinine at 36-month followup
122.6 ± 37.3
NA
144.1 ± 69.5
ns
Data shown as mean ± standard deviation if not indicated otherwise. ESRD: end-stage renal disease; CIT: cold ischemia time; PRA: panel reactive antibody; BMI: body mass index; TX: transplantation; **() BKVN versus negative control group; ns: not significant; *P values for categorical data or Fisherś test and for continuous variables Mann-Whitney U test (Student’s t-test where appropriate).
