Molecular Networks Involved in the Immune Control of BK Polyomavirus
Table 4
Genes with different regulation in polyoma BK nephropathy.
Gene
Control group
BKVN group
P value*
C3
0.06 (0.02–0.6)
0.375 (0.03–5.27)
0.022
CCL2
0.06 (0.01–0.12)
0.22 (0.03–0.85)
0.005
CCL3
0.12 (0–0.65)
0.71 (0.16–5.89)
0.02
CCL5
3.26 (0.41–45.4)
66.9 (7.9–235)
0.003
CCR2
0 (0–6.38)
20.7 (0–158)
0.001
CCR7
0 (0–659)
35.3 (0–789)
0.017
CD19
0 (0–104)
109 (0–2440)
0.013
CD28
1.36 (0–75.1)
59.3 (0.74–448)
0.012
CD4
3.32 (0.22–15.1)
27 (6.63–209)
0.004
CD68
0.61 (0.05–1.38)
1.68 (0.97–4.79)
0.001
CD86
0.67 (0.01–16.9)
10 (0.88–32.3)
0.012
CSF1
1.42 (0.02–4.89)
5.17 (0.57–71.3)
0.049
CXCL10
0.05 (0–2.9)
1.8 (0.06–3.76)
0.015
CXCR3
0 (0–34.3)
61.2 (0–671)
0.013
EDN1
0.45 (0.14–1.32)
1.18 (0.39–8.74)
0.025
FASL
0 (0–67.2)
145.72 (25.96–409.25)
0.003
GNLY
0.36 (0.12–2.1)
4.9 (1.45–52.2)
0.001
HLADRA
0.39 (0.15–3.27)
1.55 (0.503–7.6)
0.021
HLA-DRB1
0 (0–0.39)
0.85 (0–85.6)
0.036
ICAM1
0.03 (0–0.8)
0.235 (0.06–13.1)
0.03
IFNG
2.65 (0–139)
82.1 (0–519)
0.023
IL12B
0 (0–3.83)
3.49 (0–37.6)
0.03
IL1B
0.17 (0–0.95)
1.38 (0.3–3.67)
0.002
IL2RA
0.14 (0–3.44)
3.32 (0.47–19)
0.009
IL6
0.05 (0.01–3.49)
0.72 (0.07–9.49)
0.048
IL8
0.55 (0–6.75)
14.7 (0.11–53.4)
0.004
LTA
0 (0–93.9)
68.8 (0–903)
0.036
PRF1
8.7 (0–43.3)
117 (1.4–4100)
0.007
PTPRC
1.52 (0.55–24.6)
47.6 (4.7–303)
0.001
TBX21
0 (0–15.2)
7.14 (0–383)
0.036
TGFB
0.73 (0.23–6.75)
3.42 (0.73–13)
0.025
TNF
0.61 (0.04–3.18)
8.2 (0.95–30.7)
0.002
TNFRSF18
0 (0–1.77)
1.7 (0–19.5)
0.01
Data are shown as median (minimum–maximum) of relative quantity (RQ) of gene expression calculated with regard to the reference gene (GAPDH) and calibrator.
*
P values calculated by Mann-Whitney U test followed by the Bonferroni adjustment.
