Immune Modulation in Primary Vaccinia virus Zoonotic Human Infections
Aspects of the immune responses in mice infected or not with zoonotic Vaccinia virus. Peripheral blood mononuclear cells (PBMCs) from mice either infected with a zoonotic Vaccinia virus isolate or noninfected were cultured for 72 hours in the presence of UV-inactivated VACV. After incubation, cells were labeled with specific antibodies and analyzed by flow cytometry. (a) Percentage of total monocytes (CD14+); (b) percentage of CD4+ T lymphocytes expressing the CD25 surface activation marker; (c) percentage of CD8+ T lymphocytes. Bars represent the mean results from 10 animals. Error bars and values are indicated.
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