IgG Placental Transfer in Healthy and Pathological Pregnancies
Table 1
Serum immunoglobulin levels, specific antibody concentrations and avidity indexes in the maternal and cord serum and cord/maternal serum ratios for IgG antibodies from a mother with CVID.
Maternal
Cord
Placental Transfer ratio (%)
Total Immunoglobulin Concentrations
IgG (mg/dL)
473.0
912.0
190
IgM (mg/dL)
<6.0
12.0
–
IgA (mg/dL)
<3.0
<3.0
–
IgG1 (mg/dL)
362.0
752.0
210
IgG2 (mg/dL)
249.0
192.0
80
IgG3 (mg/dL)
10.0
20.0
200
IgG4 (mg/dL)
6.0
21.0
350
Specific IgG Antibodies Levels
IgG anti-tetanus toxoid (UI/mL)
1.6
3.1
190
IgG anti-Hib PRP* (mg/L)
3.8
3.7
100
IgG anti-PS§1 (mg/L)/avidity (M)+
2.3/>3.0
2.6/>3.0
110
IgG anti-PS3 (mg/L)/avidity (M)
2.4/>3.0
2.8/>3.0
120
IgG anti-PS5 (mg/L)/avidity (M)
7.3/2.7
8.0/2.7
110
IgG anti-PS6 (mg/L)/avidity (M)
6.9/2.7
6.6/>3.0
100
IgG anti-PS9 (mg/L)/avidity (M)
4.4/2.9
4.7/>3.0
110
IgG anti-PS14 (mg/L)/avidity (M)
12.8/2.5
15.0/2.8
120
–IgM and IgA maternal/cord blood ratios were not performed;
*PRP—polyribosyl–ribitolphosphate polymers; §Anti-PS—Anti-Streptococcus pneumoniae polysaccharide; +(M) —Avidity index in molarity.
