Table of Contents Author Guidelines Submit a Manuscript
Clinical and Developmental Immunology
Volume 2013, Article ID 107321, 11 pages
http://dx.doi.org/10.1155/2013/107321
Research Article

NFAT Signaling in Osteoblasts Regulates the Hematopoietic Niche in the Bone Microenvironment

Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA

Received 14 January 2013; Accepted 6 March 2013

Academic Editor: Giacomina Brunetti

Copyright © 2013 Cheryl L. Sesler and Majd Zayzafoon. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. Macian, “NFAT proteins: key regulators of T-cell development and function,” Nature Reviews Immunology, vol. 5, no. 6, pp. 472–484, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. M. K. Choo, H. Yeo, and M. Zayzafoon, “NFATc1 mediates HDAC-dependent transcriptional repression of osteocalcin expression during osteoblast differentiation,” Bone, vol. 45, no. 3, pp. 579–589, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. H. Yeo, L. H. Beck, S. R. Thompson et al., “Conditional disruption of calcineurin B1 in osteoblasts increases bone formation and reduces bone resorption,” Journal of Biological Chemistry, vol. 282, no. 48, pp. 35318–35327, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. M. R. Müller and A. Rao, “NFAT, immunity and cancer: a transcription factor comes of age,” Nature Reviews Immunology, vol. 10, no. 9, pp. 645–656, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. T. Koga, Y. Matsui, M. Asagiri et al., “NFAT and osterix cooperatively regulate bone formation,” Nature Medicine, vol. 11, no. 8, pp. 880–885, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. M. M. Winslow, M. Pan, M. Starbuck et al., “Calcineurin/NFAT signaling in osteoblasts regulates bone mass,” Developmental Cell, vol. 10, no. 6, pp. 771–782, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Sun, H. C. Blair, Y. Peng et al., “Calcineurin regulates bone formation by the osteoblast,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 47, pp. 17130–17135, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Zanotti, A. Smerdel-Ramoya, and E. Canalis, “Reciprocal regulation of Notch and nuclear factor of activated T-cells (NFAT) c1 transactivation in osteoblasts,” Journal of Biological Chemistry, vol. 286, no. 6, pp. 4576–4588, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Zanotti and A. Smerdel-Ramoya, “Canalis E Nuclear factor of activated T-cells (NFAT)C2 inhibits Notch receptor signaling in osteoblasts,” Journal of Biological Chemistry, vol. 288, pp. 624–632, 2013. View at Google Scholar · View at Scopus
  10. H. Yeo, L. H. Beck, J. M. McDonald, and M. Zayzafoon, “Cyclosporin A elicits dose-dependent biphasic effects on osteoblast differentiation and bone formation,” Bone, vol. 40, no. 6, pp. 1502–1516, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Srinivasan, B. J. Ausk, J. Prasad et al., “Rescuing loading induced bone formation at senescence,” PLoS Computational Biology, vol. 6, no. 9, Article ID e1000924, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. L. M. Calvi, G. B. Adams, K. W. Weibrecht et al., “Osteoblastic cells regulate the haematopoietic stem cell niche,” Nature, vol. 425, no. 6960, pp. 841–846, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Coskun and K. K. Hirschi, “Establishment and regulation of the HSC niche: roles of osteoblastic and vascular compartments,” Birth Defects Research C, vol. 90, no. 4, pp. 229–242, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. H. G. Kopp, S. T. Avecilla, A. T. Hooper, and S. Rafii, “The bone marrow vascular niche: home of HSC differentiation and mobilization,” Physiology, vol. 20, no. 5, pp. 349–356, 2005. View at Google Scholar · View at Scopus
  15. G. B. Adams and D. T. Scadden, “The hematopoietic stem cell in its place,” Nature Immunology, vol. 7, no. 4, pp. 333–337, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Shiozawa, Y. Jung, A. M. Ziegler et al., “Erythropoietin couples hematopoiesis with bone formation,” PloS One, vol. 5, no. 5, Article ID e10853, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Zhang, C. Niu, L. Ye et al., “Identification of the haematopoietic stem cell niche and control of the niche size,” Nature, vol. 425, no. 6960, pp. 836–841, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. M. J. Kiel, G. L. Radice, and S. J. Morrison, “Lack of evidence that hematopoietic stem cells depend on N-cadherin-mediated adhesion to osteoblasts for their maintenance,” Cell Stem Cell, vol. 1, no. 2, pp. 204–217, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. B. R. Chitteti, Y. H. Cheng, B. Poteat et al., “Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell function,” Blood, vol. 115, no. 16, pp. 3239–3248, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. K. Miyake, K. Medina, K. Ishihara, M. Kimoto, R. Auerbach, and P. W. Kincade, “A VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture,” Journal of Cell Biology, vol. 114, no. 3, pp. 557–565, 1991. View at Google Scholar · View at Scopus
  21. D. H. Schaumann, J. Tuischer, W. Ebell, R. A. Manz, and R. Lauster, “VCAM-1-positive stromal cells from human bone marrow producing cytokines for B lineage progenitors and for plasma cells: SDF-1, flt3L, and BAFF,” Molecular Immunology, vol. 44, no. 7, pp. 1606–1612, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. K. L. Quinlan, S. M. Naik, G. Cannon et al., “Substance P activates coincident NF-AT- and NF-κB-dependent adhesion molecule gene expression in microvascular endothelial cells through intracellular calcium mobilization,” Journal of Immunology, vol. 163, no. 10, pp. 5656–5665, 1999. View at Google Scholar · View at Scopus
  23. T. Minami, M. Miura, W. C. Aird, and T. Kodama, “Thrombin-induced autoinhibitory factor, Down syndrome critical region-1, attenuates NFAT-dependent vascular cell adhesion molecule-1 expression and inflammation in the endothelium,” Journal of Biological Chemistry, vol. 281, no. 29, pp. 20503–20520, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. A. W. Orr, M. Y. Lee, J. A. Lemmon et al., “Molecular mechanisms of collagen isotype-specific modulation of smooth muscle cell phenotype,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 29, no. 2, pp. 225–231, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. C. W. Chow, M. Rincón, and R. J. Davis, “Requirement for transcription factor NFAT in interleukin-2 expression,” Molecular and Cellular Biology, vol. 19, no. 3, pp. 2300–2307, 1999. View at Google Scholar · View at Scopus
  26. J. Rossert, H. Eberspaecher, and B. De Crombrugghe, “Separate cis-acting DNA elements of the mouse Pro-α1(I) collagen promoter direct expression of reporter genes to different type I collagen-producing cells in transgenic mice,” Journal of Cell Biology, vol. 129, no. 5, pp. 1421–1432, 1995. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Zayzafoon, K. Fulzele, and J. M. McDonald, “Calmodulin and calmodulin-dependent kinase IIα regulate osteoblast differentiation by controlling c-fos expression,” Journal of Biological Chemistry, vol. 280, no. 8, pp. 7049–7059, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Cain, B. McLelland, N. M. Collette, G. G. Loots, and J. O. Manilay, “Absence of sclerostin adversely affects B-cell survival,” Journal of Bone and Mineral Research, vol. 27, no. 7, pp. 1451–1461, 2012. View at Publisher · View at Google Scholar
  29. H. Yeo, J. M. Mcdonald, and M. Zayzafoon, “NFATc1: a novel anabolic therapeutic target for osteoporosis,” Annals of the New York Academy of Sciences, vol. 1068, no. 1, pp. 564–567, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. W. Bauer, M. Rauner, S. Kujawski et al., “Osteomyelosclerosis, anemia and extramedullary hematopoiesis in mice lacking the transcription factor NFATc2,” Haematologica, vol. 96, no. 11, pp. 1580–1588, 2011. View at Publisher · View at Google Scholar
  31. J. Zhu, R. Garrett, Y. Jung et al., “Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells,” Blood, vol. 109, no. 9, pp. 3706–3712, 2007. View at Publisher · View at Google Scholar
  32. Y. Jung, J. Song, Y. Shiozawa et al., “Hematopoietic stem cells regulate mesenchymal stromal cell induction into osteoblasts thereby participating in the formation of the stem cell niche,” Stem Cells, vol. 26, no. 8, pp. 2042–2051, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. J. Fric, C. X. F. Lim, B. Hofmann et al., “Calcineurin/NFAT signalling inhibits myeloid haematopoiesis,” EMBO Molecular Medicine, vol. 4, no. 4, pp. 269–282, 2012. View at Publisher · View at Google Scholar
  34. D. Visnjic, Z. Kalajzic, D. W. Rowe, V. Katavic, J. Lorenzo, and H. L. Aguila, “Hematopoiesis is severely altered in mice with an induced osteoblast deficiency,” Blood, vol. 103, no. 9, pp. 3258–3264, 2004. View at Publisher · View at Google Scholar · View at Scopus
  35. M. R. Du, H. L. Piao, M. Q. Li, C. L. Tang, and D. J. Li, “Cyclosporin A promotes crosstalk between human cytotrophoblast and decidual stromal cell through up-regulating CXCL12/CXCR4 interaction,” Human Reproduction, vol. 27, no. 7, pp. 1955–1965, 2012. View at Publisher · View at Google Scholar
  36. T. J. LaRocca, D. Jeong, E. Kohlbrenner et al., “CXCR4 gene transfer prevents pressure overload induced heart failure,” Journal of Molecular and Cellular Cardiology, vol. 53, no. 2, pp. 223–232, 2012. View at Publisher · View at Google Scholar
  37. R. Hofmeister, A. R. Khaled, N. Benbernou, E. Rajnavolgyi, K. Muegge, and S. K. Durum, “Interleukin-7: physiological roles and mechanisms of action,” Cytokine and Growth Factor Reviews, vol. 10, no. 1, pp. 41–60, 1999. View at Publisher · View at Google Scholar · View at Scopus
  38. A. K. Patra, A. Avots, R. P. Zahedi et al., “An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development,” Nature Immunology, vol. 14, no. 2, pp. 127–135, 2013. View at Publisher · View at Google Scholar