Dextromethorphan Inhibits Activations and Functions in Dendritic Cells

Figure 2

DXM impaired the release of cytokines and chemokines from LPS-stimulated BMDCs. Immature BMDCs were stimulated with 100 ng/mL LPS with or without DXM. The control group was treated with PBS alone. Culture supernatants were collected after 18 h (4 h for TNF-alpha and RANTES), and cytokines and chemokines were quantified by ELISA. Data are presented as the means ± SD of samples from three wells. Significant differences between DXM-treated and untreated LPS-activated BMDCs are shown with asterisks (^∗𝑃<0.05, ^∗∗𝑃<0.01). All data are representative of three independent experiments.

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