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Clinical and Developmental Immunology
Volume 2013 (2013), Article ID 145725, 7 pages
Research Article

Association of Human Leukocyte Antigen Class I Polymorphism with Spontaneous Clearance of Hepatitis B Surface Antigen in Qidong Han Population

1Medical School, Ministry of Education, Southeast University, Nanjing, Jiangsu 210009, China
2Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, Jiangsu 210096, China
3The Second Affiliated Hospital of Southeast University, Nanjing, Jiangsu 210008, China

Received 29 May 2013; Revised 27 September 2013; Accepted 29 September 2013

Academic Editor: Basak Kayhan

Copyright © 2013 Fengqin Miao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. To investigate whether HLA class I polymorphisms could influence the clearance of hepatitis B surface antigen (HBsAg) in Qidong Han population. Methods. We genotyped HLA-A, -B, and -C loci of 448 individuals with HBV persistent infection and 140 persons with spontaneous clearance of HBsAg by polymerase chain reaction with sequencing based typing (PCR/SBT). All the individuals were unrelated males enrolled from Qidong Han population and were followed up for 10 years. Results. The frequency of HLA-A*33:03:01G was increased in persistent HBV infection group ( value is 0.028), while frequency of HLA-B*13:01:01G was increased in HBsAg clearance group ( value is 0.0004). Conclusion. These findings suggested that the host HLA class I polymorphism is an important factor in determining the outcomes of HBV infection.