Evaluation of Clinical Interest of Anti-Aquaporin-4 Autoantibody Followup in Neuromyelitis Optica
Figure 3
Detailed evolution of anti-AQP4 serum reactivity and comparison with disease course in patients 7 to 10. Serum anti-AQP4 Ab concentration (black triangle) was measured with a cell-based assay using AQP4 expressing human 293 T cells and flow cytometry as described in Section 2. EDSS score indicates the level of impairment (grey circle); vertical dashed arrows represent relapses (all relapses were treated with corticosteroids); horizontal arrows indicate a treatment (RTX: rituximab (1 perfusion weekly of 375 mg/m2 during 4 weeks); CYC: cyclophosphamide; PE: plasma exchange; AZA: azathioprine).
