Molecular Pathogenesis of B-Cell Posttransplant Lymphoproliferative Disorder: What Do We Know So Far?

Table 1

Most common genetic and epigenetic alterations detected in B-cell posttransplant lymphoma.

Translocations involving	Copy number variations		DNA mutations	DNA polymorphisms	Epigenetic alterations
	Losses	Gains		Host genome
8q24 (C-MYC); 3q27 (BCL-6); 14q32 (IgH, TCL1)	1p	2p24-p25 (CD138)	PIM1; PAX5; C-MYC; RhoH/TTF	IL-10; TGF-beta; IFN-gamma; TNF-alpha; HLA	DAP-k; MGMT; SHP1; TP73
	1q (LOH)	3q27 (BCL-6)
	2p16.1 (FRA2E: FANCL, VRK2)	4q21.21; 5p
	6q (PRDM1, TNFAIP3)	7q; 8q24 (C-MYC)		EBV genome; LMP1; BZLF1
	9p (LOH)	9 (EBV+)
	10q (LOH)	9p
	11q (LOH)	11 (EBV+)
	12	11p
	17p13 (TP53)	12p
	17p	12q
	18q	18q21 (BCL-2, MALT1)
	4q (rare)
	Xp (rare)	21q

Abbreviations: EBV: Epstein-Barr Virus; FRA: fragile site; LOH: loss of heterozygosity.