Immunological Reaction in TNF-α-Mediated Osteoclast Formation and Bone Resorption In Vitro and In Vivo

Figure 2

The mechanism of IL-12-, IL-18-, and IFN-γ-induced apoptosis in bone marrow cell culture. TNF-α induced the expression of Fas on preosteoclast, and IL-12 and IL-18 induce the expression of FasL on nonadherent cells. The Fas/FasL interaction induced the apoptosis of preosteoclast in bone marrow cell culture.