Polarization and function of activated microglia in CNS autoimmune inflammation. Microglia are activated by diverse stimuli, which define the polarization status of the cell. While IFN-γ/LPS promote the proinflammatory M1 status, IL-4/IL-10 or IL-13 induce the anti-inflammatory M2 status. M1 microglia take part in the attraction and differentiation of pathogenic / T-cells, whereas M2 microglia promote phagocytosis of myelin debris, which is important for remyelination.
