Treatment with CB₂ Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice

Figure 2

Selective CB₂ activation decreases ROS content in corpus cavernosum. JWH-133 decreases ROS content in corpus cavernosum of ApoE^−/− mice. (a) Quantification of ROS content. ((b)–(d)) Representative photomicrographs of penis sections showing the ROS production using DHE staining in wild type mice (b) and untreated (c) and treated (d) ApoE^−/− mice. *𝑃<0.05 (one-way ANOVA followed by Bonferroni posttest). Each column represents the mean ± SEM (𝑛=6) of relative fluorescence in arbitrary unity (A.U.).